Alveolar Bone Ridge Augmentation Using Polymeric Membranes: A Systematic Review and Meta-Analysis

• Main Authors: Manuel Toledano-Osorio, Manuel Toledano, Francisco Javier Manzano-Moreno, Cristina Vallecillo, Marta Vallecillo-Rivas, Alberto Rodriguez-Archilla, Raquel Osorio
• Format: Article
• Language: English
• Published: MDPI AG 2021-04-01
• Series: Polymers
• Subjects: bone regeneration; polymeric membrane; bone substitutes; ridge augmentation
• Online Access: https://www.mdpi.com/2073-4360/13/7/1172

Alveolar bone ridge resorption occurred after natural teeth loss and it can restrict the possibility of dental implants placement. The use of bone regenerative procedures is frequently required. The existing evidence regarding the efficacy of horizontal bone ridge augmentation trough guided bone regeneration (GBR) using polymeric membranes was stated. A systematic review and meta-analysis were performed. Electronic and manual literature searches were conducted. Screening process was done using the National Library of Medicine (MEDLINE by PubMed), Embase, and the Cochrane Oral Health. Included articles were randomized controlled trials and observational studies. Weighted means were calculated. Heterogeneity was determined using Higgins (<i>I</i>2). If I2 > 50% a random-effects model was applied. It was found that the mean of horizontal bone gain was 3.95 mm, ranging from 3.19 to 4.70 mm (confidence interval 95%). Heterogeneity is I2 = 99% (confidence interval 95%) and significance of the random-effects model was <i>p</i> < 0.001. The complications rate was 8.4% and membrane exposure was the most frequent. Through this study, we were able to conclude that the existing scientific evidence suggests that GBR using polymeric membranes is a predictable technique for achieving horizontal bone augmentation, thus, permitting a proper further implant placement.