Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis

Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis

Abstract Background Despite the important role that microRNAs (miRNAs) play in immunity and inflammation, their involvement in systemic sclerosis (SSc) remains poorly characterized. miRNA-155 (miR-155) plays a role in pulmonary fibrosis and its expression can be induced with interleukin (IL)-1β. SSc...

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Bibliographic Details
Main Authors: Carol M. Artlett, Sihem Sassi-Gaha, Jennifer L. Hope, Carol A. Feghali-Bostwick, Peter D. Katsikis
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Arthritis Research & Therapy
Subjects:
Fibrosis
NLRP3 inflammasome
miR-155
Systemic sclerosis
IL-1
Online Access:http://link.springer.com/article/10.1186/s13075-017-1331-z

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