The Presence of Serum TgAb Suggests Lower Risks for Glucose and Lipid Metabolic Disorders in Euthyroid General Population From a National Survey
Purpose: The expressions of antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) are very common in the sera of patients with autoimmune thyroid diseases (AITD). The relationship between thyroid autoantibodies and the occurrence of glucose and lipid metabolic disorders remains uncl...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-03-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.00139/full |
| id |
doaj-a8dcbc82385445a2bf6bc14141dddfee |
|---|---|
| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jinjia Zhang Yiyang Gao Yongze Li Di Teng Yuanming Xue Li Yan Jing Yang Lihui Yang Yongli Yao Jianming Ba Bing Chen Jianling Du Lanjie He Xiaoyang Lai Xiaochun Teng Xiaoguang Shi Yanbo Li Haiyi Chi Eryuan Liao Chao Liu Libin Liu Guijun Qin Yingfen Qin Huibiao Quan Bingyin Shi Hui Sun Xulei Tang Nanwei Tong Guixia Wang Jin-an Zhang Youmin Wang Zhen Ye Qiao Zhang Lihui Zhang Jun Zhu Mei Zhu Weiping Teng Zhongyan Shan Jing Li |
| spellingShingle |
Jinjia Zhang Yiyang Gao Yongze Li Di Teng Yuanming Xue Li Yan Jing Yang Lihui Yang Yongli Yao Jianming Ba Bing Chen Jianling Du Lanjie He Xiaoyang Lai Xiaochun Teng Xiaoguang Shi Yanbo Li Haiyi Chi Eryuan Liao Chao Liu Libin Liu Guijun Qin Yingfen Qin Huibiao Quan Bingyin Shi Hui Sun Xulei Tang Nanwei Tong Guixia Wang Jin-an Zhang Youmin Wang Zhen Ye Qiao Zhang Lihui Zhang Jun Zhu Mei Zhu Weiping Teng Zhongyan Shan Jing Li The Presence of Serum TgAb Suggests Lower Risks for Glucose and Lipid Metabolic Disorders in Euthyroid General Population From a National Survey Frontiers in Endocrinology glucose lipid TPOAb TgAb IFG hypertriglyceridemia |
| author_facet |
Jinjia Zhang Yiyang Gao Yongze Li Di Teng Yuanming Xue Li Yan Jing Yang Lihui Yang Yongli Yao Jianming Ba Bing Chen Jianling Du Lanjie He Xiaoyang Lai Xiaochun Teng Xiaoguang Shi Yanbo Li Haiyi Chi Eryuan Liao Chao Liu Libin Liu Guijun Qin Yingfen Qin Huibiao Quan Bingyin Shi Hui Sun Xulei Tang Nanwei Tong Guixia Wang Jin-an Zhang Youmin Wang Zhen Ye Qiao Zhang Lihui Zhang Jun Zhu Mei Zhu Weiping Teng Zhongyan Shan Jing Li |
| author_sort |
Jinjia Zhang |
| title |
The Presence of Serum TgAb Suggests Lower Risks for Glucose and Lipid Metabolic Disorders in Euthyroid General Population From a National Survey |
| title_short |
The Presence of Serum TgAb Suggests Lower Risks for Glucose and Lipid Metabolic Disorders in Euthyroid General Population From a National Survey |
| title_full |
The Presence of Serum TgAb Suggests Lower Risks for Glucose and Lipid Metabolic Disorders in Euthyroid General Population From a National Survey |
| title_fullStr |
The Presence of Serum TgAb Suggests Lower Risks for Glucose and Lipid Metabolic Disorders in Euthyroid General Population From a National Survey |
| title_full_unstemmed |
The Presence of Serum TgAb Suggests Lower Risks for Glucose and Lipid Metabolic Disorders in Euthyroid General Population From a National Survey |
| title_sort |
presence of serum tgab suggests lower risks for glucose and lipid metabolic disorders in euthyroid general population from a national survey |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Endocrinology |
| issn |
1664-2392 |
| publishDate |
2020-03-01 |
| description |
Purpose: The expressions of antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) are very common in the sera of patients with autoimmune thyroid diseases (AITD). The relationship between thyroid autoantibodies and the occurrence of glucose and lipid metabolic disorders remains unclear. This study was performed to investigate the correlation between the presence of serum TPOAb/TgAb and those metabolic disorders in euthyroid general population.Methods: The data of this study were derived from the Thyroid Disease, Iodine status, and Diabetes National epidemiological (TIDE) survey from all 31 provinces of mainland China. A total of 17,964 euthyroid subjects including 5,802 males (4,000 with TPOAb−TgAb− and 1,802 with TPOAb+/TgAb+) and 12,162 females (8,000 with TPOAb−TgAb− and 4,162 with TPOAb+/TgAb+) were enrolled in this study. The blood glucose and lipid levels were compared between individuals with TPOAb−TgAb− and those with TPOAb+TgAb−, TPOAb−TgAb+, TPOAb+TgAb+.Results: Both fasting blood glucose (FBG) concentration and the proportion of individuals with impaired FBG (IFG) showed the decreased trends in TPOAb−TgAb+ males as compared with TPOAb−TgAb− men. There were significantly lower FBG and higher HDL-C levels as well as tendencies toward decreased incidences of IGT and hypertriglyceridemia in TPOAb−TgAb+ females when compared with TPOAb−TgAb− women. Binary logistic regression analysis further showed that serum TgAb single positivity in males was an independent protective factor for IFG with an OR of 0.691 (95% CI, 0.503–0.949). For females, serum TgAb single positivity was an independent protective factor for hypertriglyceridemia with an OR of 0.859 (95% CI, 0.748–0.987). Trend test showed that with the increase of serum TgAb level, there were significant decreases in the prevalence of IFG among the men with TSH ≤ 2.5 mIU/L and that of hypertriglyceridemia in the women, especially among non-obese females.Conclusion: Serum TgAb single positivity may imply a reduced risk of IFG in euthyroid men and that of hypertriglyceridemia in euthyroid women. The mechanisms for the independent protective roles of TgAb await further investigation. |
| topic |
glucose lipid TPOAb TgAb IFG hypertriglyceridemia |
| url |
https://www.frontiersin.org/article/10.3389/fendo.2020.00139/full |
| work_keys_str_mv |
AT jinjiazhang thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT yiyanggao thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT yongzeli thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT diteng thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT yuanmingxue thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT liyan thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT jingyang thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT lihuiyang thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT yongliyao thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT jianmingba thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT bingchen thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT jianlingdu thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT lanjiehe thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT xiaoyanglai thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT xiaochunteng thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT xiaoguangshi thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT yanboli thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT haiyichi thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT eryuanliao thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT chaoliu thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT libinliu thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT guijunqin thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT yingfenqin thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT huibiaoquan thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT bingyinshi thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT huisun thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT xuleitang thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT nanweitong thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT guixiawang thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT jinanzhang thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT youminwang thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT zhenye thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT qiaozhang thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT lihuizhang thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT junzhu thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT meizhu thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT weipingteng thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT zhongyanshan thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT jingli thepresenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT jinjiazhang presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT yiyanggao presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT yongzeli presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT diteng presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT yuanmingxue presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT liyan presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT jingyang presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT lihuiyang presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT yongliyao presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT jianmingba presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT bingchen presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT jianlingdu presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT lanjiehe presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT xiaoyanglai presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT xiaochunteng presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT xiaoguangshi presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT yanboli presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT haiyichi presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT eryuanliao presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT chaoliu presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT libinliu presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT guijunqin presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT yingfenqin presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT huibiaoquan presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT bingyinshi presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT huisun presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT xuleitang presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT nanweitong presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT guixiawang presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT jinanzhang presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT youminwang presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT zhenye presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT qiaozhang presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT lihuizhang presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT junzhu presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT meizhu presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT weipingteng presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT zhongyanshan presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey AT jingli presenceofserumtgabsuggestslowerrisksforglucoseandlipidmetabolicdisordersineuthyroidgeneralpopulationfromanationalsurvey |
| _version_ |
1724991814596820992 |
| spelling |
doaj-a8dcbc82385445a2bf6bc14141dddfee2020-11-25T01:53:18ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-03-011110.3389/fendo.2020.00139523777The Presence of Serum TgAb Suggests Lower Risks for Glucose and Lipid Metabolic Disorders in Euthyroid General Population From a National SurveyJinjia Zhang0Yiyang Gao1Yongze Li2Di Teng3Yuanming Xue4Li Yan5Jing Yang6Lihui Yang7Yongli Yao8Jianming Ba9Bing Chen10Jianling Du11Lanjie He12Xiaoyang Lai13Xiaochun Teng14Xiaoguang Shi15Yanbo Li16Haiyi Chi17Eryuan Liao18Chao Liu19Libin Liu20Guijun Qin21Yingfen Qin22Huibiao Quan23Bingyin Shi24Hui Sun25Xulei Tang26Nanwei Tong27Guixia Wang28Jin-an Zhang29Youmin Wang30Zhen Ye31Qiao Zhang32Lihui Zhang33Jun Zhu34Mei Zhu35Weiping Teng36Zhongyan Shan37Jing Li38Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Endocrinology, The First People's Hospital of Yunnan Province, Kunming, ChinaDepartment of Endocrinology and Metabolism, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Endocrinology and Metabolism, People's Hospital of Tibet Autonomous Region, Lhasa, ChinaDepartment of Endocrinology, Qinghai Provincial People's Hospital, Xining, ChinaDepartment of Endocrinology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, China0Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital of Ningxia Medical University, Yinchuan, China1Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China2Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China3Department of Endocrinology, Hohhot First Hospital, Hohhot, China4Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China5Research Center of Endocrine and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China6Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China7Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China8Department of Endocrine, First Affiliated Hospital of Guangxi Medical University, Nanning, China9Department of Endocrinology, Hainan General Hospital, Haikou, China0Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China1Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China2Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, China3State Key Laboratory of Biotherapy, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China4Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China5Department of Endocrinology, Shanghai University of Medicine & Health Science Affiliated Zhoupu Hospital, Shanghai, China6Department of Endocrinology, The First Hospital of Anhui Medical University, Hefei, China7Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China8Department of Endocrinology and Metabolism, Affiliated Hospital of Guiyang Medical University, Guiyang, China9Department of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, China0Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, ChinaPurpose: The expressions of antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) are very common in the sera of patients with autoimmune thyroid diseases (AITD). The relationship between thyroid autoantibodies and the occurrence of glucose and lipid metabolic disorders remains unclear. This study was performed to investigate the correlation between the presence of serum TPOAb/TgAb and those metabolic disorders in euthyroid general population.Methods: The data of this study were derived from the Thyroid Disease, Iodine status, and Diabetes National epidemiological (TIDE) survey from all 31 provinces of mainland China. A total of 17,964 euthyroid subjects including 5,802 males (4,000 with TPOAb−TgAb− and 1,802 with TPOAb+/TgAb+) and 12,162 females (8,000 with TPOAb−TgAb− and 4,162 with TPOAb+/TgAb+) were enrolled in this study. The blood glucose and lipid levels were compared between individuals with TPOAb−TgAb− and those with TPOAb+TgAb−, TPOAb−TgAb+, TPOAb+TgAb+.Results: Both fasting blood glucose (FBG) concentration and the proportion of individuals with impaired FBG (IFG) showed the decreased trends in TPOAb−TgAb+ males as compared with TPOAb−TgAb− men. There were significantly lower FBG and higher HDL-C levels as well as tendencies toward decreased incidences of IGT and hypertriglyceridemia in TPOAb−TgAb+ females when compared with TPOAb−TgAb− women. Binary logistic regression analysis further showed that serum TgAb single positivity in males was an independent protective factor for IFG with an OR of 0.691 (95% CI, 0.503–0.949). For females, serum TgAb single positivity was an independent protective factor for hypertriglyceridemia with an OR of 0.859 (95% CI, 0.748–0.987). Trend test showed that with the increase of serum TgAb level, there were significant decreases in the prevalence of IFG among the men with TSH ≤ 2.5 mIU/L and that of hypertriglyceridemia in the women, especially among non-obese females.Conclusion: Serum TgAb single positivity may imply a reduced risk of IFG in euthyroid men and that of hypertriglyceridemia in euthyroid women. The mechanisms for the independent protective roles of TgAb await further investigation.https://www.frontiersin.org/article/10.3389/fendo.2020.00139/fullglucoselipidTPOAbTgAbIFGhypertriglyceridemia |