Prognostic Value of Growth Differentiation Factor 15 in Kidney Donors and Recipients
Growth differentiation factor-15 (GDF15) is associated with inflammatory conditions, chronic kidney disease, cardiovascular disease and mortality. There is very limited data on GDF15 after kidney donation and transplantation. We analyzed serum samples of patients who donated a kidney (54 living dono...
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doaj-a8e27913403d47118096babec5e81c5d2020-11-25T02:54:37ZengMDPI AGJournal of Clinical Medicine2077-03832020-05-0191333133310.3390/jcm9051333Prognostic Value of Growth Differentiation Factor 15 in Kidney Donors and RecipientsUlrich Jehn0Katharina Schütte-Nütgen1Ute Henke2Joachim Bautz3Hermann Pavenstädt4Barbara Suwelack5Stefan Reuter6Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, 48149 Münster, GermanyDepartment of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, 48149 Münster, GermanyDepartment of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, 48149 Münster, GermanyDepartment of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, 48149 Münster, GermanyDepartment of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, 48149 Münster, GermanyDepartment of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, 48149 Münster, GermanyDepartment of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, 48149 Münster, GermanyGrowth differentiation factor-15 (GDF15) is associated with inflammatory conditions, chronic kidney disease, cardiovascular disease and mortality. There is very limited data on GDF15 after kidney donation and transplantation. We analyzed serum samples of patients who donated a kidney (54 living donors) or who underwent kidney transplantation (104 recipients) at the University Hospital of Münster (Germany) between 2013 and 2015, for GDF15 levels immediately prior and one year after surgery. GDF15 levels were significantly elevated in end-stage renal disease patients compared to healthy individuals (2844 (IQR 2087, 3361) pg/ml vs. 384 (IQR 307, 487) pg/ml, <i>p</i> < 0.001). GDF15 was strongly associated with the dialysis vintage. While kidney transplantation led to a significant decrease of GDF15 (913 (IQR 674, 1453) pg/ml, <i>p</i> < 0.001), kidney donation caused a moderate increase of GDF15 (510 (IQR 420, 626), <i>p</i> < 0.001) one year after surgery. GDF15 levels remained significantly higher in recipients and kidney donors than in healthy controls (735 (IQR 536, 1202) pg/ml vs. 384 (IQR 307, 487) pg/ml, <i>p</i> < 0.001). GDF15 is increased in patients with kidney disease and is associated with dialysis vintage. Given its decrease after transplantation and its increase after uni-nephrectomy, GDF15 might be a marker of kidney function. However, since it correlates only to the eGFR in transplanted patients it may indicate chronic kidney disease.https://www.mdpi.com/2077-0383/9/5/1333kidney transplantationrenal diseasegrowth differentiation factor-15GDF15living donationdialysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ulrich Jehn Katharina Schütte-Nütgen Ute Henke Joachim Bautz Hermann Pavenstädt Barbara Suwelack Stefan Reuter |
spellingShingle |
Ulrich Jehn Katharina Schütte-Nütgen Ute Henke Joachim Bautz Hermann Pavenstädt Barbara Suwelack Stefan Reuter Prognostic Value of Growth Differentiation Factor 15 in Kidney Donors and Recipients Journal of Clinical Medicine kidney transplantation renal disease growth differentiation factor-15 GDF15 living donation dialysis |
author_facet |
Ulrich Jehn Katharina Schütte-Nütgen Ute Henke Joachim Bautz Hermann Pavenstädt Barbara Suwelack Stefan Reuter |
author_sort |
Ulrich Jehn |
title |
Prognostic Value of Growth Differentiation Factor 15 in Kidney Donors and Recipients |
title_short |
Prognostic Value of Growth Differentiation Factor 15 in Kidney Donors and Recipients |
title_full |
Prognostic Value of Growth Differentiation Factor 15 in Kidney Donors and Recipients |
title_fullStr |
Prognostic Value of Growth Differentiation Factor 15 in Kidney Donors and Recipients |
title_full_unstemmed |
Prognostic Value of Growth Differentiation Factor 15 in Kidney Donors and Recipients |
title_sort |
prognostic value of growth differentiation factor 15 in kidney donors and recipients |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-05-01 |
description |
Growth differentiation factor-15 (GDF15) is associated with inflammatory conditions, chronic kidney disease, cardiovascular disease and mortality. There is very limited data on GDF15 after kidney donation and transplantation. We analyzed serum samples of patients who donated a kidney (54 living donors) or who underwent kidney transplantation (104 recipients) at the University Hospital of Münster (Germany) between 2013 and 2015, for GDF15 levels immediately prior and one year after surgery. GDF15 levels were significantly elevated in end-stage renal disease patients compared to healthy individuals (2844 (IQR 2087, 3361) pg/ml vs. 384 (IQR 307, 487) pg/ml, <i>p</i> < 0.001). GDF15 was strongly associated with the dialysis vintage. While kidney transplantation led to a significant decrease of GDF15 (913 (IQR 674, 1453) pg/ml, <i>p</i> < 0.001), kidney donation caused a moderate increase of GDF15 (510 (IQR 420, 626), <i>p</i> < 0.001) one year after surgery. GDF15 levels remained significantly higher in recipients and kidney donors than in healthy controls (735 (IQR 536, 1202) pg/ml vs. 384 (IQR 307, 487) pg/ml, <i>p</i> < 0.001). GDF15 is increased in patients with kidney disease and is associated with dialysis vintage. Given its decrease after transplantation and its increase after uni-nephrectomy, GDF15 might be a marker of kidney function. However, since it correlates only to the eGFR in transplanted patients it may indicate chronic kidney disease. |
topic |
kidney transplantation renal disease growth differentiation factor-15 GDF15 living donation dialysis |
url |
https://www.mdpi.com/2077-0383/9/5/1333 |
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