Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis

Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis

The cyclooxygenase-2 (COX-2) is a potent enzyme that converts arachidonic acid to prostaglandins (PG), including PGE2, a key mediator of inflammation and angiogenesis. Importantly, COX-2 is activated in response to inflammatory stimuli, where it is also believed to promote the development and progre...

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Bibliographic Details
Main Authors: Ellen Frejborg, Tuula Salo, Abdelhakim Salem
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
cyclooxygenase-2
head and neck cancers
head and neck squamous cell carcinoma
prostaglandins
inflammation
carcinogenesis
Online Access:https://www.mdpi.com/1422-0067/21/23/9246

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