HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada
Abstract Men who have sex with men (MSM) are disproportionately affected by anal cancer, predominantly caused by high-risk (HR) human papillomavirus (HPV) infection. Currently, the nonavalent HPV vaccine provides coverage against nine HPV genotypes, including seven HR-HPV genotypes. Here, we charact...
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2021-02-01
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Online Access: | https://doi.org/10.1038/s41598-021-84079-y |
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doaj-a8f2f8fba1bc486fa57b7c682b8e1f0b2021-03-11T12:12:02ZengNature Publishing GroupScientific Reports2045-23222021-02-0111111010.1038/s41598-021-84079-yHPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, CanadaYoojin Choi0Mona Loutfy1Robert S. Remis2Juan Liu3Anuradha Rebbapragada4Sanja Huibner5Jason Brunetta6Graham Smith7Tatjana Reko8Roberta Halpenny9Rupert Kaul10Troy Grennan11Department of Immunology, University of TorontoDalla Lana School of Public Health, University of TorontoDalla Lana School of Public Health, University of TorontoPublic Health Laboratory-Toronto, Public Health OntarioCanada HealthLabsDepartment of Medicine, University of TorontoMaple Leaf Medical ClinicMaple Leaf Medical ClinicGlaxoSmithKlineMaple Leaf Medical ClinicDepartment of Immunology, University of TorontoBC Centre for Disease ControlAbstract Men who have sex with men (MSM) are disproportionately affected by anal cancer, predominantly caused by high-risk (HR) human papillomavirus (HPV) infection. Currently, the nonavalent HPV vaccine provides coverage against nine HPV genotypes, including seven HR-HPV genotypes. Here, we characterize anal HR-HPV genotype distribution and associated risk factors in MSM from Toronto, Canada recruited between September 2010 and June 2012. Wilcoxon–Mann–Whitney test was used for continuous variables, Chi-square test was performed for categorical variables, and a multivariable model using logistic regression was created to assess for correlates of anal HR-HPV infection. A total of 442 MSM were recruited, with a median age of 45 (IQR 38–50) and an overall HPV prevalence of 82%. The prevalence of any HR-HPV infection was 65.3% and 50.7% in the HIV-positive and HIV-negative MSM, respectively. No participant tested positive for all genotypes covered by the nonavalent vaccine. HIV status (aOR 1.806; 95% CI 1.159–2.816), smoking (aOR 2.176; 95% CI 1.285–3.685) and the number of lifetime sexual partners (aOR 2.466; 95% CI 1.092–5.567) were independent risk factors for anal HR-HPV infection. Our findings will be useful to inform HPV vaccine rollout and HPV prevention strategies in Canadian MSM.https://doi.org/10.1038/s41598-021-84079-y |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yoojin Choi Mona Loutfy Robert S. Remis Juan Liu Anuradha Rebbapragada Sanja Huibner Jason Brunetta Graham Smith Tatjana Reko Roberta Halpenny Rupert Kaul Troy Grennan |
spellingShingle |
Yoojin Choi Mona Loutfy Robert S. Remis Juan Liu Anuradha Rebbapragada Sanja Huibner Jason Brunetta Graham Smith Tatjana Reko Roberta Halpenny Rupert Kaul Troy Grennan HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada Scientific Reports |
author_facet |
Yoojin Choi Mona Loutfy Robert S. Remis Juan Liu Anuradha Rebbapragada Sanja Huibner Jason Brunetta Graham Smith Tatjana Reko Roberta Halpenny Rupert Kaul Troy Grennan |
author_sort |
Yoojin Choi |
title |
HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada |
title_short |
HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada |
title_full |
HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada |
title_fullStr |
HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada |
title_full_unstemmed |
HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada |
title_sort |
hpv genotyping and risk factors for anal high-risk hpv infection in men who have sex with men from toronto, canada |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-02-01 |
description |
Abstract Men who have sex with men (MSM) are disproportionately affected by anal cancer, predominantly caused by high-risk (HR) human papillomavirus (HPV) infection. Currently, the nonavalent HPV vaccine provides coverage against nine HPV genotypes, including seven HR-HPV genotypes. Here, we characterize anal HR-HPV genotype distribution and associated risk factors in MSM from Toronto, Canada recruited between September 2010 and June 2012. Wilcoxon–Mann–Whitney test was used for continuous variables, Chi-square test was performed for categorical variables, and a multivariable model using logistic regression was created to assess for correlates of anal HR-HPV infection. A total of 442 MSM were recruited, with a median age of 45 (IQR 38–50) and an overall HPV prevalence of 82%. The prevalence of any HR-HPV infection was 65.3% and 50.7% in the HIV-positive and HIV-negative MSM, respectively. No participant tested positive for all genotypes covered by the nonavalent vaccine. HIV status (aOR 1.806; 95% CI 1.159–2.816), smoking (aOR 2.176; 95% CI 1.285–3.685) and the number of lifetime sexual partners (aOR 2.466; 95% CI 1.092–5.567) were independent risk factors for anal HR-HPV infection. Our findings will be useful to inform HPV vaccine rollout and HPV prevention strategies in Canadian MSM. |
url |
https://doi.org/10.1038/s41598-021-84079-y |
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