Prediction of Pathologic Complete Response by Ultrasonography and Magnetic Resonance Imaging After Neoadjuvant Chemotherapy in Patients with Breast Cancer
Kai Zhang,* Jiawei Li,* Qian Zhu, Cai Chang Department of Medical Ultrasound, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Cai ChangFudan University Shanghai Cancer Center, No. 270, Dong&rsqu...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Dove Medical Press
2020-04-01
|
Series: | Cancer Management and Research |
Subjects: | |
Online Access: | https://www.dovepress.com/prediction-of-pathologic-complete-response-by-ultrasonography-and-magn-peer-reviewed-article-CMAR |
id |
doaj-a90a47bd6e50472da0758ecb28479950 |
---|---|
record_format |
Article |
spelling |
doaj-a90a47bd6e50472da0758ecb284799502020-11-25T02:41:40ZengDove Medical PressCancer Management and Research1179-13222020-04-01Volume 122603261253106Prediction of Pathologic Complete Response by Ultrasonography and Magnetic Resonance Imaging After Neoadjuvant Chemotherapy in Patients with Breast CancerZhang KLi JZhu QChang CKai Zhang,* Jiawei Li,* Qian Zhu, Cai Chang Department of Medical Ultrasound, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Cai ChangFudan University Shanghai Cancer Center, No. 270, Dong’an Road, Shanghai, Xuhui District 200032, People’s Republic of ChinaTel +86 180 1731 2605Fax +86 21 6417 4774Email changc62@126.comPurpose: To compare the diagnostic performance for pathologic complete response (pCR) in breast cancer after neoadjuvant chemotherapy (NAC) between ultrasound (US) and magnetic resonance imaging (MRI).Patients and Methods: A total of 1,219 breast cancer patients with 1,232 tumors who accepted US and/or MRI examination after NAC and before breast surgery were included. The diagnostic performance of US, MRI, and US plus MRI in predicting pCR was compared.Results: The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of US for pCR were 36.2%, 90.2%, 71.0%, 67.3%, and 71.9%, respectively, while for MRI they were 44.4%, 92.9%, 75.6%, 77.7%, and 75.0%, respectively. The combination of US and MRI had increased specificity (98.0%) and PPV (86.8%), decreased sensitivity (22.5%) and NPV (68.8%), but similar accuracy (70.5%) in comparison with US or MRI alone. The prediction of pCR by imaging differed in different histological, molecular subtypes and primary tumor size.Conclusion: Neither US nor MRI could predict a pCR with sufficient accuracy. The combination of US and MRI could not predict a pCR reliably either. The explanation of imaging for pCR should take into account histological, molecular subtypes, and primary tumor size.Keywords: breast neoplasms, neoadjuvant therapy, pathologic complete response, ultrasonography, magnetic resonance imaginghttps://www.dovepress.com/prediction-of-pathologic-complete-response-by-ultrasonography-and-magn-peer-reviewed-article-CMARbreast neoplasmsneoadjuvant therapypathologic complete responseultrasonographymagnetic resonance imaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhang K Li J Zhu Q Chang C |
spellingShingle |
Zhang K Li J Zhu Q Chang C Prediction of Pathologic Complete Response by Ultrasonography and Magnetic Resonance Imaging After Neoadjuvant Chemotherapy in Patients with Breast Cancer Cancer Management and Research breast neoplasms neoadjuvant therapy pathologic complete response ultrasonography magnetic resonance imaging |
author_facet |
Zhang K Li J Zhu Q Chang C |
author_sort |
Zhang K |
title |
Prediction of Pathologic Complete Response by Ultrasonography and Magnetic Resonance Imaging After Neoadjuvant Chemotherapy in Patients with Breast Cancer |
title_short |
Prediction of Pathologic Complete Response by Ultrasonography and Magnetic Resonance Imaging After Neoadjuvant Chemotherapy in Patients with Breast Cancer |
title_full |
Prediction of Pathologic Complete Response by Ultrasonography and Magnetic Resonance Imaging After Neoadjuvant Chemotherapy in Patients with Breast Cancer |
title_fullStr |
Prediction of Pathologic Complete Response by Ultrasonography and Magnetic Resonance Imaging After Neoadjuvant Chemotherapy in Patients with Breast Cancer |
title_full_unstemmed |
Prediction of Pathologic Complete Response by Ultrasonography and Magnetic Resonance Imaging After Neoadjuvant Chemotherapy in Patients with Breast Cancer |
title_sort |
prediction of pathologic complete response by ultrasonography and magnetic resonance imaging after neoadjuvant chemotherapy in patients with breast cancer |
publisher |
Dove Medical Press |
series |
Cancer Management and Research |
issn |
1179-1322 |
publishDate |
2020-04-01 |
description |
Kai Zhang,* Jiawei Li,* Qian Zhu, Cai Chang Department of Medical Ultrasound, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Cai ChangFudan University Shanghai Cancer Center, No. 270, Dong’an Road, Shanghai, Xuhui District 200032, People’s Republic of ChinaTel +86 180 1731 2605Fax +86 21 6417 4774Email changc62@126.comPurpose: To compare the diagnostic performance for pathologic complete response (pCR) in breast cancer after neoadjuvant chemotherapy (NAC) between ultrasound (US) and magnetic resonance imaging (MRI).Patients and Methods: A total of 1,219 breast cancer patients with 1,232 tumors who accepted US and/or MRI examination after NAC and before breast surgery were included. The diagnostic performance of US, MRI, and US plus MRI in predicting pCR was compared.Results: The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of US for pCR were 36.2%, 90.2%, 71.0%, 67.3%, and 71.9%, respectively, while for MRI they were 44.4%, 92.9%, 75.6%, 77.7%, and 75.0%, respectively. The combination of US and MRI had increased specificity (98.0%) and PPV (86.8%), decreased sensitivity (22.5%) and NPV (68.8%), but similar accuracy (70.5%) in comparison with US or MRI alone. The prediction of pCR by imaging differed in different histological, molecular subtypes and primary tumor size.Conclusion: Neither US nor MRI could predict a pCR with sufficient accuracy. The combination of US and MRI could not predict a pCR reliably either. The explanation of imaging for pCR should take into account histological, molecular subtypes, and primary tumor size.Keywords: breast neoplasms, neoadjuvant therapy, pathologic complete response, ultrasonography, magnetic resonance imaging |
topic |
breast neoplasms neoadjuvant therapy pathologic complete response ultrasonography magnetic resonance imaging |
url |
https://www.dovepress.com/prediction-of-pathologic-complete-response-by-ultrasonography-and-magn-peer-reviewed-article-CMAR |
work_keys_str_mv |
AT zhangk predictionofpathologiccompleteresponsebyultrasonographyandmagneticresonanceimagingafterneoadjuvantchemotherapyinpatientswithbreastcancer AT lij predictionofpathologiccompleteresponsebyultrasonographyandmagneticresonanceimagingafterneoadjuvantchemotherapyinpatientswithbreastcancer AT zhuq predictionofpathologiccompleteresponsebyultrasonographyandmagneticresonanceimagingafterneoadjuvantchemotherapyinpatientswithbreastcancer AT changc predictionofpathologiccompleteresponsebyultrasonographyandmagneticresonanceimagingafterneoadjuvantchemotherapyinpatientswithbreastcancer |
_version_ |
1724777260870795264 |