ICAM-1 expression on chondrocytes in rheumatoid arthritis: induction by synovial cytokines
The intercellular adhesion molecule-1 (ICAM-1) was found by immunostaining chondrocytes in cartilage from three patients with rheumatoid arthritis. Expression of ICAM-1 was restricted to chondrocytes in areas of erodedcartilage adjacent to the invading synovial tissue. Toluidine blue staining of the...
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1992-01-01
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Series: | Mediators of Inflammation |
Online Access: | http://dx.doi.org/10.1155/S0962935192000140 |
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doaj-a90d031bd37544039326d8ea7a233e972020-11-24T23:02:05ZengHindawi LimitedMediators of Inflammation0962-93511466-18611992-01-0111717410.1155/S0962935192000140ICAM-1 expression on chondrocytes in rheumatoid arthritis: induction by synovial cytokinesM. E. Davies0H. Sharma1R. Pigott2Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 4RN, UKStrangeways Research Laboratory, Worts Causeway, Cambridge CB1 4RN, UKBritish Biotechnology Ltd, Watlington Road, Cowley, Oxford OX4 5LY, UKThe intercellular adhesion molecule-1 (ICAM-1) was found by immunostaining chondrocytes in cartilage from three patients with rheumatoid arthritis. Expression of ICAM-1 was restricted to chondrocytes in areas of erodedcartilage adjacent to the invading synovial tissue. Toluidine blue staining of these areas demonstrated severe depletion of the cartilage extracellular matrix. In areas of undamaged cartilage there was no ICAM-1 expression. Since ICAM-1 is not constitutively expressed on normal human articular cartilage, but could be induced in vitro by exogenous IL-1α, TNFα and IFNγ or by co-culturing cartilage with inflammatory rheumatoid synovium, we conclude that the induction of ICAM-1 on rheumatoid chondrocytes results from the synergistic action of a variety of cytokines produced by the inflammatory cells of the invading pannus.http://dx.doi.org/10.1155/S0962935192000140 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M. E. Davies H. Sharma R. Pigott |
spellingShingle |
M. E. Davies H. Sharma R. Pigott ICAM-1 expression on chondrocytes in rheumatoid arthritis: induction by synovial cytokines Mediators of Inflammation |
author_facet |
M. E. Davies H. Sharma R. Pigott |
author_sort |
M. E. Davies |
title |
ICAM-1 expression on chondrocytes in rheumatoid arthritis: induction by synovial cytokines |
title_short |
ICAM-1 expression on chondrocytes in rheumatoid arthritis: induction by synovial cytokines |
title_full |
ICAM-1 expression on chondrocytes in rheumatoid arthritis: induction by synovial cytokines |
title_fullStr |
ICAM-1 expression on chondrocytes in rheumatoid arthritis: induction by synovial cytokines |
title_full_unstemmed |
ICAM-1 expression on chondrocytes in rheumatoid arthritis: induction by synovial cytokines |
title_sort |
icam-1 expression on chondrocytes in rheumatoid arthritis: induction by synovial cytokines |
publisher |
Hindawi Limited |
series |
Mediators of Inflammation |
issn |
0962-9351 1466-1861 |
publishDate |
1992-01-01 |
description |
The intercellular adhesion molecule-1 (ICAM-1) was found by immunostaining chondrocytes in cartilage from three patients with rheumatoid arthritis. Expression of ICAM-1 was restricted to chondrocytes in areas of erodedcartilage adjacent to the invading synovial tissue. Toluidine blue staining of these areas demonstrated severe depletion of the cartilage extracellular matrix. In areas of undamaged cartilage there was no ICAM-1 expression. Since ICAM-1 is not constitutively expressed on normal human articular cartilage, but could be induced in vitro by exogenous IL-1α, TNFα and IFNγ or by co-culturing cartilage with inflammatory rheumatoid synovium, we conclude that the induction of ICAM-1 on rheumatoid chondrocytes results from the synergistic action of a variety of cytokines produced by the inflammatory cells of the invading pannus. |
url |
http://dx.doi.org/10.1155/S0962935192000140 |
work_keys_str_mv |
AT medavies icam1expressiononchondrocytesinrheumatoidarthritisinductionbysynovialcytokines AT hsharma icam1expressiononchondrocytesinrheumatoidarthritisinductionbysynovialcytokines AT rpigott icam1expressiononchondrocytesinrheumatoidarthritisinductionbysynovialcytokines |
_version_ |
1725637521008754688 |