Haploinsufficient TNAP Mice Display Decreased Extracellular ATP Levels and Expression of Pannexin-1 Channels

Haploinsufficient TNAP Mice Display Decreased Extracellular ATP Levels and Expression of Pannexin-1 Channels

Hypophosphatasia (HPP) is a rare heritable metabolic bone disease caused by hypomorphic mutations in the ALPL (in human) or Akp2 (in mouse) gene, encoding the tissue-nonspecific alkaline phosphatase (TNAP) enzyme. In addition to skeletal and dental malformations, severe forms of HPP are also charact...

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Bibliographic Details
Main Authors: Álvaro Sebastián-Serrano, Laura de Diego-García, David C. Henshall, Tobías Engel, Miguel Díaz-Hernández
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Pharmacology
Subjects:
tissue-nonspecific alkaline phosphatase (TNAP)
adenosine 5′-triphosphate (ATP)
hypophosphatasia (HPP)
P2X7 receptor (P2X7R)
pannexin 1 (Panx1)
seizure
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00170/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00170/full

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