Clinicopathologic Significance of P63, Maspin and MMP-2 Expression in Mucoepidermoid Carcinoma
Background and Aim: Mucoepidermoid carcinoma (MEC) is the most common malignant neoplasm of the salivary glands with complex histopathologic features and clinical behavior. The aim of this study was to evaluate the clinicopathologic significance of p63, Maspin and matrix metalloproteinase (MMP)-2 ex...
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doaj-a916a5efe885445b8bf2815744681e4a2020-11-25T00:49:04ZengIslamic Dental Association of IranJournal of Islamic Dental Association of Iran2383-30412383-30412017-01-012912128Clinicopathologic Significance of P63, Maspin and MMP-2 Expression in Mucoepidermoid CarcinomaNasim Taghavi0Parisa Kardouni Khozestani1Alireza Akbarzadeh Baghban2 Associate Professor, Oral & Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran Assistant Professor, Department of Oral & Maxillofacial Pathology, School of Dentistry, Gilan University of Medical Sciences, Rasht, Iran Associate Professor PhD in Biostatistics, Associate Professor, Proteomics Research Center, Department of Basic Science, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran Background and Aim: Mucoepidermoid carcinoma (MEC) is the most common malignant neoplasm of the salivary glands with complex histopathologic features and clinical behavior. The aim of this study was to evaluate the clinicopathologic significance of p63, Maspin and matrix metalloproteinase (MMP)-2 expression in MEC. Materials and Methods: In this retrospective study, immunohistochemical staining was performed to detect the expression of p63, Maspin and MMP-2 in 35 cases of MEC. In addition, to detect the presence of myoepithelial differentiation, smooth muscle actin (SMA) staining was performed. Data were analyzed using non-parametric tests. Results: P63 expression, intensity of staining for p63 and MMP-2 total score showed significant correlations with histologic grade (P=0.008, P=0.035 and P=0.003, respectively). The association between p63 expression and MMP-2 total score was significant (P=0.033). P63 positive cases did not express SMA. Conclusion: Findings suggest that p63 and MMP-2 may be useful prognostic indicators in MEC. MEC is devoid of myoepithelial cells.http://jidai.ir/browse.php?a_code=A-10-1-873&slc_lang=en&sid=1TP63 ProteinHumanSERPIN-B5Matrix Metalloproteinase 2CarcinomaMucoepidermoid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nasim Taghavi Parisa Kardouni Khozestani Alireza Akbarzadeh Baghban |
spellingShingle |
Nasim Taghavi Parisa Kardouni Khozestani Alireza Akbarzadeh Baghban Clinicopathologic Significance of P63, Maspin and MMP-2 Expression in Mucoepidermoid Carcinoma Journal of Islamic Dental Association of Iran TP63 Protein Human SERPIN-B5 Matrix Metalloproteinase 2 Carcinoma Mucoepidermoid |
author_facet |
Nasim Taghavi Parisa Kardouni Khozestani Alireza Akbarzadeh Baghban |
author_sort |
Nasim Taghavi |
title |
Clinicopathologic Significance of P63, Maspin and MMP-2
Expression in Mucoepidermoid Carcinoma |
title_short |
Clinicopathologic Significance of P63, Maspin and MMP-2
Expression in Mucoepidermoid Carcinoma |
title_full |
Clinicopathologic Significance of P63, Maspin and MMP-2
Expression in Mucoepidermoid Carcinoma |
title_fullStr |
Clinicopathologic Significance of P63, Maspin and MMP-2
Expression in Mucoepidermoid Carcinoma |
title_full_unstemmed |
Clinicopathologic Significance of P63, Maspin and MMP-2
Expression in Mucoepidermoid Carcinoma |
title_sort |
clinicopathologic significance of p63, maspin and mmp-2
expression in mucoepidermoid carcinoma |
publisher |
Islamic Dental Association of Iran |
series |
Journal of Islamic Dental Association of Iran |
issn |
2383-3041 2383-3041 |
publishDate |
2017-01-01 |
description |
Background and Aim: Mucoepidermoid carcinoma (MEC) is the most common malignant neoplasm of the salivary glands with complex histopathologic features and clinical behavior. The aim of this study was to evaluate the clinicopathologic significance of p63, Maspin and matrix metalloproteinase (MMP)-2 expression in MEC.
Materials and Methods: In this retrospective study, immunohistochemical staining was performed to detect the expression of p63, Maspin and MMP-2 in 35 cases of MEC. In addition, to detect the presence of myoepithelial differentiation, smooth muscle actin (SMA) staining was performed. Data were analyzed using non-parametric tests.
Results: P63 expression, intensity of staining for p63 and MMP-2 total score showed significant correlations with histologic grade (P=0.008, P=0.035 and P=0.003, respectively). The association between p63 expression and MMP-2 total score was significant (P=0.033). P63 positive cases did not express SMA.
Conclusion: Findings suggest that p63 and MMP-2 may be useful prognostic indicators in MEC. MEC is devoid of myoepithelial cells. |
topic |
TP63 Protein Human SERPIN-B5 Matrix Metalloproteinase 2 Carcinoma Mucoepidermoid |
url |
http://jidai.ir/browse.php?a_code=A-10-1-873&slc_lang=en&sid=1 |
work_keys_str_mv |
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