| Summary: | The objective of this study was to evaluate the clinical effectiveness of surgical reconstruction of aortic valve using autologous pericardium, and the hemodynamic impact of matching the circumferential direction of the trimmed leaflet to inherent fiber orientation of the pericardium during surgery. A patient specific aortic valve model was built based on CTA data. The reconstructive surgery was carried out on the model following normal operating procedures. FSI simulation was performed to analyze the hemodynamic characteristics among the diseased model, normal model and three operative models with different misaligned angles between the circumferential direction of the substitute and inherent fiber orientation. The differences of EOA, velocity distribution, stress and strain on leaflets, and the valve deformation between the five models were compared and analyzed. The results showed that reconstructive surgery helps enlarge EOA, reduce abnormity of leaflet motion and blood ejection compared to diseased model. There was no significant difference between operative models with different misaligned angles in terms of leaflet motion and flow pattern, but as the misaligned angle increased, greater strain and deformation were observed on leaflets during the diastolic period. The present study demonstrated the instant clinical effectiveness of the reconstructive surgery of aortic valve by the improvement of EOA and flow pattern, and suggested that during the operation it may be unnecessary to match the circumferential direction of the substitute to inherent fiber orientation of the pericardium since the hemodynamic characteristics were insensitive to the fiber alignment, but the strain and deformation increment on the substitutes during diastolic period still raised concern about their durability.
|
|---|
