Direct and Intestinal Epithelial Cell-Mediated Effects of TLR8 Triggering on Human Dendritic Cells, CD14+CD16+ Monocytes and γδ T Lymphocytes

Direct and Intestinal Epithelial Cell-Mediated Effects of TLR8 Triggering on Human Dendritic Cells, CD14+CD16+ Monocytes and γδ T Lymphocytes

Toll-like receptor (TLR)7/8 plays a crucial role in host recognition/response to viruses and its mucosal expression directly correlates with intestinal inflammation. The aim of this study was to investigate the role of TLR7/8 stimulation of intestinal epithelium in shaping the phenotype and function...

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Bibliographic Details
Main Authors: Costanza Angelini, Barbara Varano, Patrizia Puddu, Maurizio Fiori, Antonella Baldassarre, Andrea Masotti, Sandra Gessani, Lucia Conti
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
cell activation
pathogen recognition
inflammation
microenvironment
adjuvant
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01813/full

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