Stent Thrombosis Patients with Hyporesponsiveness to Clopidogrel, Prasugrel, and Ticagrelor: A Case Series Using Short Thromboelastography

Stent Thrombosis Patients with Hyporesponsiveness to Clopidogrel, Prasugrel, and Ticagrelor: A Case Series Using Short Thromboelastography

Patients after percutaneous coronary intervention (PCI) with stent implantation and functional hyporesponsiveness to P2Y12 inhibitors are at higher risk of ischaemic events, particularly stent thrombosis (ST). It is currently not routine practice to assess the functional response to these agents. Ho...

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Main Authors: Bartosz Olechowski, Alexander Ashby, Nalyaka Sambu, Michael Mahmoudi, Nick Curzen
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Case Reports in Medicine
Online Access:http://dx.doi.org/10.1155/2016/2096181
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spelling doaj-a9276fe141c241e69910a01415dbb6082020-11-24T23:49:12ZengHindawi LimitedCase Reports in Medicine1687-96271687-96352016-01-01201610.1155/2016/20961812096181Stent Thrombosis Patients with Hyporesponsiveness to Clopidogrel, Prasugrel, and Ticagrelor: A Case Series Using Short ThromboelastographyBartosz Olechowski0Alexander Ashby1Nalyaka Sambu2Michael Mahmoudi3Nick Curzen4Wessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UKWessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UKWessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UKWessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UKWessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UKPatients after percutaneous coronary intervention (PCI) with stent implantation and functional hyporesponsiveness to P2Y12 inhibitors are at higher risk of ischaemic events, particularly stent thrombosis (ST). It is currently not routine practice to assess the functional response to these agents. However, concern over functional hyporesponsiveness to clopidogrel has led to widespread uptake of prasugrel and ticagrelor as the default P2Y12 inhibitor after stent implantation in patients with acute coronary syndrome. Here we report, for the first time, 3 cases in which patients who have had ST exhibit hyporesponsiveness to clopidogrel, prasugrel, and ticagrelor.http://dx.doi.org/10.1155/2016/2096181
collection DOAJ
language English
format Article
sources DOAJ
author Bartosz Olechowski
Alexander Ashby
Nalyaka Sambu
Michael Mahmoudi
Nick Curzen
spellingShingle Bartosz Olechowski
Alexander Ashby
Nalyaka Sambu
Michael Mahmoudi
Nick Curzen
Stent Thrombosis Patients with Hyporesponsiveness to Clopidogrel, Prasugrel, and Ticagrelor: A Case Series Using Short Thromboelastography
Case Reports in Medicine
author_facet Bartosz Olechowski
Alexander Ashby
Nalyaka Sambu
Michael Mahmoudi
Nick Curzen
author_sort Bartosz Olechowski
title Stent Thrombosis Patients with Hyporesponsiveness to Clopidogrel, Prasugrel, and Ticagrelor: A Case Series Using Short Thromboelastography
title_short Stent Thrombosis Patients with Hyporesponsiveness to Clopidogrel, Prasugrel, and Ticagrelor: A Case Series Using Short Thromboelastography
title_full Stent Thrombosis Patients with Hyporesponsiveness to Clopidogrel, Prasugrel, and Ticagrelor: A Case Series Using Short Thromboelastography
title_fullStr Stent Thrombosis Patients with Hyporesponsiveness to Clopidogrel, Prasugrel, and Ticagrelor: A Case Series Using Short Thromboelastography
title_full_unstemmed Stent Thrombosis Patients with Hyporesponsiveness to Clopidogrel, Prasugrel, and Ticagrelor: A Case Series Using Short Thromboelastography
title_sort stent thrombosis patients with hyporesponsiveness to clopidogrel, prasugrel, and ticagrelor: a case series using short thromboelastography
publisher Hindawi Limited
series Case Reports in Medicine
issn 1687-9627
1687-9635
publishDate 2016-01-01
description Patients after percutaneous coronary intervention (PCI) with stent implantation and functional hyporesponsiveness to P2Y12 inhibitors are at higher risk of ischaemic events, particularly stent thrombosis (ST). It is currently not routine practice to assess the functional response to these agents. However, concern over functional hyporesponsiveness to clopidogrel has led to widespread uptake of prasugrel and ticagrelor as the default P2Y12 inhibitor after stent implantation in patients with acute coronary syndrome. Here we report, for the first time, 3 cases in which patients who have had ST exhibit hyporesponsiveness to clopidogrel, prasugrel, and ticagrelor.
url http://dx.doi.org/10.1155/2016/2096181
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AT alexanderashby stentthrombosispatientswithhyporesponsivenesstoclopidogrelprasugrelandticagreloracaseseriesusingshortthromboelastography
AT nalyakasambu stentthrombosispatientswithhyporesponsivenesstoclopidogrelprasugrelandticagreloracaseseriesusingshortthromboelastography
AT michaelmahmoudi stentthrombosispatientswithhyporesponsivenesstoclopidogrelprasugrelandticagreloracaseseriesusingshortthromboelastography
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