Intraperitoneal Gemcitabine Chemotherapy Treatment for Patients with Resected Pancreatic Cancer: Rationale and Report of Early Data
Currently, the surgical management of pancreas cancer is recognized around the world as inadequate. Despite a potentially curative R0 resection, long-term survival is rare. There is a strong rationale for the use of chemotherapy in the operating room to reduce local-regional of recurrent/progressive...
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doaj-a92bec87d4ec4db79a3c6637223fd9492020-11-24T22:20:49ZengHindawi LimitedInternational Journal of Surgical Oncology2090-14022090-14102011-01-01201110.1155/2011/161862161862Intraperitoneal Gemcitabine Chemotherapy Treatment for Patients with Resected Pancreatic Cancer: Rationale and Report of Early DataPaul H. Sugarbaker0O. Anthony Stuart1Lana Bijelic2Washington Cancer Institute, 106 Irving Street, NW, Suite 3900, Washington, DC 20010, USAWashington Cancer Institute, 106 Irving Street, NW, Suite 3900, Washington, DC 20010, USAWashington Cancer Institute, 106 Irving Street, NW, Suite 3900, Washington, DC 20010, USACurrently, the surgical management of pancreas cancer is recognized around the world as inadequate. Despite a potentially curative R0 resection, long-term survival is rare. There is a strong rationale for the use of chemotherapy in the operating room to reduce local-regional of recurrent/progressive disease. Gemcitabine monotherapy administered by an intraperitoneal route in the operating room with hyperthermia and then for long-term treatment postoperatively has a pharmacologic basis in that the exposure of peritoneal surfaces to intraperitoneal gemcitabine is approximately 200–500 times the exposure that occurs within the plasma. A standardized treatment with intraoperative and long-term chemotherapy that is well tolerated would greatly facilitate further improvements in pancreas cancer treatment and may lead the way to an evolution of more successful treatment strategies of this dread disease. The aim of this paper is to present the early data on a protocol in progress in patients with resected pancreatic cancer.http://dx.doi.org/10.1155/2011/161862 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paul H. Sugarbaker O. Anthony Stuart Lana Bijelic |
spellingShingle |
Paul H. Sugarbaker O. Anthony Stuart Lana Bijelic Intraperitoneal Gemcitabine Chemotherapy Treatment for Patients with Resected Pancreatic Cancer: Rationale and Report of Early Data International Journal of Surgical Oncology |
author_facet |
Paul H. Sugarbaker O. Anthony Stuart Lana Bijelic |
author_sort |
Paul H. Sugarbaker |
title |
Intraperitoneal Gemcitabine Chemotherapy Treatment for Patients with Resected Pancreatic Cancer: Rationale and Report of Early Data |
title_short |
Intraperitoneal Gemcitabine Chemotherapy Treatment for Patients with Resected Pancreatic Cancer: Rationale and Report of Early Data |
title_full |
Intraperitoneal Gemcitabine Chemotherapy Treatment for Patients with Resected Pancreatic Cancer: Rationale and Report of Early Data |
title_fullStr |
Intraperitoneal Gemcitabine Chemotherapy Treatment for Patients with Resected Pancreatic Cancer: Rationale and Report of Early Data |
title_full_unstemmed |
Intraperitoneal Gemcitabine Chemotherapy Treatment for Patients with Resected Pancreatic Cancer: Rationale and Report of Early Data |
title_sort |
intraperitoneal gemcitabine chemotherapy treatment for patients with resected pancreatic cancer: rationale and report of early data |
publisher |
Hindawi Limited |
series |
International Journal of Surgical Oncology |
issn |
2090-1402 2090-1410 |
publishDate |
2011-01-01 |
description |
Currently, the surgical management of pancreas cancer is recognized around the world as inadequate. Despite a potentially curative R0 resection, long-term survival is rare. There is a strong rationale for the use of chemotherapy in the operating room to reduce local-regional of recurrent/progressive disease. Gemcitabine monotherapy administered by an intraperitoneal route in the operating room with hyperthermia and then for long-term treatment postoperatively has a pharmacologic basis in that the exposure of peritoneal surfaces to intraperitoneal gemcitabine is approximately 200–500 times the exposure that occurs within the plasma. A standardized treatment with intraoperative and long-term chemotherapy that is well tolerated would greatly facilitate further improvements in pancreas cancer treatment and may lead the way to an evolution of more successful treatment strategies of this dread disease. The aim of this paper is to present the early data on a protocol in progress in patients with resected pancreatic cancer. |
url |
http://dx.doi.org/10.1155/2011/161862 |
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