Histostructure of pancreas in patients with autoimmune pancreatitis type I and II: connection with the level of IgG4-positive plasma cells
Differential diagnosis of autoimmune pancreatitis apart from everything else is based on specifi cs of immunoglobulin G4 involvement into the pathogenesis. Aims: to analyze two forms of autoimmune pancreatitis and their relation to the level of IgG4-positive plasma cells. Methods and results. T...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Zaporozhye State Medical University
2014-04-01
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| Series: | Patologìâ |
| Subjects: | |
| Online Access: | http://pat.zsmu.edu.ua/article/view/25584/23051 |
| Summary: | Differential diagnosis of autoimmune pancreatitis apart from everything else is based on specifi cs of immunoglobulin G4 involvement
into the pathogenesis.
Aims: to analyze two forms of autoimmune pancreatitis and their relation to the level of IgG4-positive plasma cells.
Methods and results. The present study was conducted on 54 patients with chronic pancreatitis, from which 15 cases with autoimmune
pancreatitis were selected by using morphological and immunohistochemical methods.
Conclusion. It has been established that for autoimmune pancreatitis type I dense lymphocytic periductal infi ltrate, multilevel fi brosis,
obliterating venulitis and high IgG4-positive plasma cells in the pancreas (≥ 30 per high power fi eld) were typical. In the cases of
autoimmune pancreatitis type II, besides the specifi c histopathological signs of AIP, signifi cantly epithelial damage of pancreatic ducts
by leukocytes, low levels of IgG4-PPC in the pancreas and focal lesions on stages I-III of disease (80%) were observed.
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| ISSN: | 2306-8027 2310-1237 |