The Genomic Signature of Breast Cancer Prevention
The breast of parous postmenopausal women exhibits a specific signature that has been induced by a full term pregnancy. This signature is centered in chromatin remodeling and the epigenetic changes induced by methylation of specific genes which are important regulatory pathways induced by pregnancy....
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2014-02-01
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doaj-a9375ebc74ab4fe9bd6566595a3a50072020-11-24T23:19:01ZengMDPI AGGenes2073-44252014-02-0151658310.3390/genes5010065genes5010065The Genomic Signature of Breast Cancer PreventionJose Russo0Julia Santucci-Pereira1Irma H. Russo2The Irma H. Russo MD Breast Cancer Research Laboratory, Fox Chase Cancer Center, Temple University Health System, 333 Cottman Avenue, Philadelphia, PA 19111, USAThe Irma H. Russo MD Breast Cancer Research Laboratory, Fox Chase Cancer Center, Temple University Health System, 333 Cottman Avenue, Philadelphia, PA 19111, USAThe Irma H. Russo MD Breast Cancer Research Laboratory, Fox Chase Cancer Center, Temple University Health System, 333 Cottman Avenue, Philadelphia, PA 19111, USAThe breast of parous postmenopausal women exhibits a specific signature that has been induced by a full term pregnancy. This signature is centered in chromatin remodeling and the epigenetic changes induced by methylation of specific genes which are important regulatory pathways induced by pregnancy. Through the analysis of the genes found to be differentially methylated between women of varying parity, multiple positions at which beta-catenin production and use is inhibited were recognized. The biological importance of the pathways identified in this specific population cannot be sufficiently emphasized because they could represent a safeguard mechanism mediating the protection of the breast conferred by full term pregnancy.http://www.mdpi.com/2073-4425/5/1/65normal breastbreast cancergenomic signaturepreventionpregnancysplicing mechanismsmethylationchromatin remodelingLnc-RNAbeta-catenin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jose Russo Julia Santucci-Pereira Irma H. Russo |
spellingShingle |
Jose Russo Julia Santucci-Pereira Irma H. Russo The Genomic Signature of Breast Cancer Prevention Genes normal breast breast cancer genomic signature prevention pregnancy splicing mechanisms methylation chromatin remodeling Lnc-RNA beta-catenin |
author_facet |
Jose Russo Julia Santucci-Pereira Irma H. Russo |
author_sort |
Jose Russo |
title |
The Genomic Signature of Breast Cancer Prevention |
title_short |
The Genomic Signature of Breast Cancer Prevention |
title_full |
The Genomic Signature of Breast Cancer Prevention |
title_fullStr |
The Genomic Signature of Breast Cancer Prevention |
title_full_unstemmed |
The Genomic Signature of Breast Cancer Prevention |
title_sort |
genomic signature of breast cancer prevention |
publisher |
MDPI AG |
series |
Genes |
issn |
2073-4425 |
publishDate |
2014-02-01 |
description |
The breast of parous postmenopausal women exhibits a specific signature that has been induced by a full term pregnancy. This signature is centered in chromatin remodeling and the epigenetic changes induced by methylation of specific genes which are important regulatory pathways induced by pregnancy. Through the analysis of the genes found to be differentially methylated between women of varying parity, multiple positions at which beta-catenin production and use is inhibited were recognized. The biological importance of the pathways identified in this specific population cannot be sufficiently emphasized because they could represent a safeguard mechanism mediating the protection of the breast conferred by full term pregnancy. |
topic |
normal breast breast cancer genomic signature prevention pregnancy splicing mechanisms methylation chromatin remodeling Lnc-RNA beta-catenin |
url |
http://www.mdpi.com/2073-4425/5/1/65 |
work_keys_str_mv |
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