EFFECT OF PHLEBODIUM DECUMANUM ON THE IMMUNE RESPONSE INDUCED BY TRAINING IN SEDENTARY UNIVERSITY STUDENTS

Exercise training is considered a good model to provoke different degrees of immune dysfunction affecting physical performance and some physiological responses related to oxidative stress and low grade inflammation. Phlebodium decumanum is a polypodiaceae may induce shown immunomodulating effects, s...

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Main Authors: Jose A. Gonzalez-Jurado, Francisco Pradas, Edgardo S. Molina, Carlos de Teresa
Format: Article
Language:English
Published: University of Uludag 2011-06-01
Series:Journal of Sports Science and Medicine
Subjects:
IL6
Online Access:http://www.jssm.org/vol10/n2/10/v10n2-10text.php
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spelling doaj-a940b1779beb4872a35a95d0ee6b78942020-11-24T23:32:00ZengUniversity of UludagJournal of Sports Science and Medicine1303-29682011-06-01102315321EFFECT OF PHLEBODIUM DECUMANUM ON THE IMMUNE RESPONSE INDUCED BY TRAINING IN SEDENTARY UNIVERSITY STUDENTSJose A. Gonzalez-JuradoFrancisco PradasEdgardo S. MolinaCarlos de TeresaExercise training is considered a good model to provoke different degrees of immune dysfunction affecting physical performance and some physiological responses related to oxidative stress and low grade inflammation. Phlebodium decumanum is a polypodiaceae may induce shown immunomodulating effects, specifically directed to the release of proinflammatory cytokines by macrophages in response to various stimuli, as reported different in vitro studies. The aim of this study was to evaluate the modulating effect of phlebodium decumanum, on the immune response induced by physical exercise. Thirty-one subjects (males only) were randomly divided into two groups: Group PD (n = 18); age: 22.1 ± 1.81, weight 74.21 ± 8.74 kg) that was treated with phlebodium decumanum; Group P (n = 13); age: 22.5 ± 1.63, weight 78 ± 12.5 kg) that was treated with a placebo. Before and after one month training program performed by both groups (three times a week), the following performance parameters and immune response variables were measured: Dynamic Maximum Force; Interval-Training; Tennis test; pro-inflammatory (TNF , IL6) and anti-inflammatory (TNFα-IIrs, IL1-ra) cytokines levels. Data were statistically analyzed with Mann- Whitney U test and Wilcoxon paired test (p < 0.05). Statistically significant differences were recorded within groups before and after the training program. PD group showed a significant improvement in the performance parameters (Strength Muscle Test: dorsal: p < 0.002; deltoids: p < 0.03; and pectorals: p < 0.07; Interval Training: p < 0.06; Tennis Test: p < 0.02). Cytokine levels resulted in a more positive profile in the PD group rather than in the P group, in which higher levels of IL-6 (p < 0.02) and a reduction of TNF-IIrs (p < 0.003) and IL1-ra (p < 0.03) were recorded. In this study the use of phlebodium decumanum demonstrated beneficial effects in the modulation of the immune response during physical performancehttp://www.jssm.org/vol10/n2/10/v10n2-10text.phpPhysical exerciseinmunomodulationTNFαIL6TNF-IIrsIL1-ra
collection DOAJ
language English
format Article
sources DOAJ
author Jose A. Gonzalez-Jurado
Francisco Pradas
Edgardo S. Molina
Carlos de Teresa
spellingShingle Jose A. Gonzalez-Jurado
Francisco Pradas
Edgardo S. Molina
Carlos de Teresa
EFFECT OF PHLEBODIUM DECUMANUM ON THE IMMUNE RESPONSE INDUCED BY TRAINING IN SEDENTARY UNIVERSITY STUDENTS
Journal of Sports Science and Medicine
Physical exercise
inmunomodulation
TNFα
IL6
TNF-IIrs
IL1-ra
author_facet Jose A. Gonzalez-Jurado
Francisco Pradas
Edgardo S. Molina
Carlos de Teresa
author_sort Jose A. Gonzalez-Jurado
title EFFECT OF PHLEBODIUM DECUMANUM ON THE IMMUNE RESPONSE INDUCED BY TRAINING IN SEDENTARY UNIVERSITY STUDENTS
title_short EFFECT OF PHLEBODIUM DECUMANUM ON THE IMMUNE RESPONSE INDUCED BY TRAINING IN SEDENTARY UNIVERSITY STUDENTS
title_full EFFECT OF PHLEBODIUM DECUMANUM ON THE IMMUNE RESPONSE INDUCED BY TRAINING IN SEDENTARY UNIVERSITY STUDENTS
title_fullStr EFFECT OF PHLEBODIUM DECUMANUM ON THE IMMUNE RESPONSE INDUCED BY TRAINING IN SEDENTARY UNIVERSITY STUDENTS
title_full_unstemmed EFFECT OF PHLEBODIUM DECUMANUM ON THE IMMUNE RESPONSE INDUCED BY TRAINING IN SEDENTARY UNIVERSITY STUDENTS
title_sort effect of phlebodium decumanum on the immune response induced by training in sedentary university students
publisher University of Uludag
series Journal of Sports Science and Medicine
issn 1303-2968
publishDate 2011-06-01
description Exercise training is considered a good model to provoke different degrees of immune dysfunction affecting physical performance and some physiological responses related to oxidative stress and low grade inflammation. Phlebodium decumanum is a polypodiaceae may induce shown immunomodulating effects, specifically directed to the release of proinflammatory cytokines by macrophages in response to various stimuli, as reported different in vitro studies. The aim of this study was to evaluate the modulating effect of phlebodium decumanum, on the immune response induced by physical exercise. Thirty-one subjects (males only) were randomly divided into two groups: Group PD (n = 18); age: 22.1 ± 1.81, weight 74.21 ± 8.74 kg) that was treated with phlebodium decumanum; Group P (n = 13); age: 22.5 ± 1.63, weight 78 ± 12.5 kg) that was treated with a placebo. Before and after one month training program performed by both groups (three times a week), the following performance parameters and immune response variables were measured: Dynamic Maximum Force; Interval-Training; Tennis test; pro-inflammatory (TNF , IL6) and anti-inflammatory (TNFα-IIrs, IL1-ra) cytokines levels. Data were statistically analyzed with Mann- Whitney U test and Wilcoxon paired test (p < 0.05). Statistically significant differences were recorded within groups before and after the training program. PD group showed a significant improvement in the performance parameters (Strength Muscle Test: dorsal: p < 0.002; deltoids: p < 0.03; and pectorals: p < 0.07; Interval Training: p < 0.06; Tennis Test: p < 0.02). Cytokine levels resulted in a more positive profile in the PD group rather than in the P group, in which higher levels of IL-6 (p < 0.02) and a reduction of TNF-IIrs (p < 0.003) and IL1-ra (p < 0.03) were recorded. In this study the use of phlebodium decumanum demonstrated beneficial effects in the modulation of the immune response during physical performance
topic Physical exercise
inmunomodulation
TNFα
IL6
TNF-IIrs
IL1-ra
url http://www.jssm.org/vol10/n2/10/v10n2-10text.php
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