Exploring conformational equilibria of a heterodimeric ABC transporter

Exploring conformational equilibria of a heterodimeric ABC transporter

ABC exporters pump substrates across the membrane by coupling ATP-driven movements of nucleotide binding domains (NBDs) to the transmembrane domains (TMDs), which switch between inward- and outward-facing (IF, OF) orientations. DEER measurements on the heterodimeric ABC exporter TM287/288 from Therm...

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Bibliographic Details
Main Authors: M Hadi Timachi, Cedric AJ Hutter, Michael Hohl, Tufa Assafa, Simon Böhm, Anshumali Mittal, Markus A Seeger, Enrica Bordignon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
electron paramagnetic resonance
DEER
ABC transporter
Online Access:https://elifesciences.org/articles/20236

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