Does the PI3K pathway promote or antagonise regulatory T cell development and function?

Regulatory T cells (Tregs) prevent autoimmunity and inflammation by suppressing the activation of other T cells and antigen presenting cells. The role of phosphoinositide 3-kinase (PI3K) signalling in Treg is controversial. Some studies suggest that inhibition of the PI3K pathway is essential for th...

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Main Authors:	Dalya R Soond, Elizabeth CM Slack, Oliver A Garden, Daniel T Patton, Klaus eOkkenhaug
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2012-08-01
Series:	Frontiers in Immunology
Subjects:	Autoimmunity Inflammation Akt T cell PI3K mTOR
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00244/full

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spelling	doaj-a946a0bb2be547ef8a8c0ef2335db53b2020-11-24T22:39:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242012-08-01310.3389/fimmu.2012.0024427252Does the PI3K pathway promote or antagonise regulatory T cell development and function?Dalya R Soond0Elizabeth CM Slack1Elizabeth CM Slack2Oliver A Garden3Daniel T Patton4Klaus eOkkenhaug5Babraham InstituteBabraham InstituteThe Royal Veterinary CollegeThe Royal Veterinary CollegeUniversity of British ColumbiaBabraham InstituteRegulatory T cells (Tregs) prevent autoimmunity and inflammation by suppressing the activation of other T cells and antigen presenting cells. The role of phosphoinositide 3-kinase (PI3K) signalling in Treg is controversial. Some studies suggest that inhibition of the PI3K pathway is essential for the development of Tregs whereas other studies have shown reduced Treg numbers and function when PI3K activity is suppressed. Here we attempt to reconcile the different studies that have explored PI3K and the downstream effectors Akt, Foxo and mTOR in regulatory T cell development and function and discuss the implications for health and therapeutic intervention.http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00244/fullAutoimmunityInflammationAktT cellPI3KmTOR
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Dalya R Soond Elizabeth CM Slack Elizabeth CM Slack Oliver A Garden Daniel T Patton Klaus eOkkenhaug
spellingShingle	Dalya R Soond Elizabeth CM Slack Elizabeth CM Slack Oliver A Garden Daniel T Patton Klaus eOkkenhaug Does the PI3K pathway promote or antagonise regulatory T cell development and function? Frontiers in Immunology Autoimmunity Inflammation Akt T cell PI3K mTOR
author_facet	Dalya R Soond Elizabeth CM Slack Elizabeth CM Slack Oliver A Garden Daniel T Patton Klaus eOkkenhaug
author_sort	Dalya R Soond
title	Does the PI3K pathway promote or antagonise regulatory T cell development and function?
title_short	Does the PI3K pathway promote or antagonise regulatory T cell development and function?
title_full	Does the PI3K pathway promote or antagonise regulatory T cell development and function?
title_fullStr	Does the PI3K pathway promote or antagonise regulatory T cell development and function?
title_full_unstemmed	Does the PI3K pathway promote or antagonise regulatory T cell development and function?
title_sort	does the pi3k pathway promote or antagonise regulatory t cell development and function?
publisher	Frontiers Media S.A.
series	Frontiers in Immunology
issn	1664-3224
publishDate	2012-08-01
description	Regulatory T cells (Tregs) prevent autoimmunity and inflammation by suppressing the activation of other T cells and antigen presenting cells. The role of phosphoinositide 3-kinase (PI3K) signalling in Treg is controversial. Some studies suggest that inhibition of the PI3K pathway is essential for the development of Tregs whereas other studies have shown reduced Treg numbers and function when PI3K activity is suppressed. Here we attempt to reconcile the different studies that have explored PI3K and the downstream effectors Akt, Foxo and mTOR in regulatory T cell development and function and discuss the implications for health and therapeutic intervention.
topic	Autoimmunity Inflammation Akt T cell PI3K mTOR
url	http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00244/full
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Does the PI3K pathway promote or antagonise regulatory T cell development and function?

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