Apathy and Executive Function in Healthy Elderly—Resting State fMRI Study
Apathy is a quantitative reduction in goal-directed behaviors, having three subtypes. Despite executive deterioration in healthy aging, researchers have not investigated the “cognitive-deficit” subtype of apathy in healthy populations, which would result from executive dysfunction. We hypothesized t...
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doaj-a9528c7e599b45e7aa4373f8c99ee0f42020-11-24T22:30:28ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652017-05-01910.3389/fnagi.2017.00124263893Apathy and Executive Function in Healthy Elderly—Resting State fMRI StudyToshikazu Kawagoe0Keiichi Onoda1Shuhei Yamaguchi2epartment of Neurology, Shimane UniversityIzumo, Japanepartment of Neurology, Shimane UniversityIzumo, Japanepartment of Neurology, Shimane UniversityIzumo, JapanApathy is a quantitative reduction in goal-directed behaviors, having three subtypes. Despite executive deterioration in healthy aging, researchers have not investigated the “cognitive-deficit” subtype of apathy in healthy populations, which would result from executive dysfunction. We hypothesized that a relationship between apathy and executive function (EF) would be found in healthy older adults, accompanied with neural deterioration with functional dysconnectivity between the striatum and frontal region as suggested by previous studies. A total of 100 healthy adults in a health examination system database were analyzed. The present study indicates that apathy is substantially associated with executive deterioration, which can be partially ascribed to decreased functional connectivity between the frontal and ventral striatum. Despite some limitations, our findings may contribute to research on healthy psychological aging.http://journal.frontiersin.org/article/10.3389/fnagi.2017.00124/fullage-related deteriorationexecutive functioncognitive apathyneuroimagingfrontostriatal network |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Toshikazu Kawagoe Keiichi Onoda Shuhei Yamaguchi |
spellingShingle |
Toshikazu Kawagoe Keiichi Onoda Shuhei Yamaguchi Apathy and Executive Function in Healthy Elderly—Resting State fMRI Study Frontiers in Aging Neuroscience age-related deterioration executive function cognitive apathy neuroimaging frontostriatal network |
author_facet |
Toshikazu Kawagoe Keiichi Onoda Shuhei Yamaguchi |
author_sort |
Toshikazu Kawagoe |
title |
Apathy and Executive Function in Healthy Elderly—Resting State fMRI Study |
title_short |
Apathy and Executive Function in Healthy Elderly—Resting State fMRI Study |
title_full |
Apathy and Executive Function in Healthy Elderly—Resting State fMRI Study |
title_fullStr |
Apathy and Executive Function in Healthy Elderly—Resting State fMRI Study |
title_full_unstemmed |
Apathy and Executive Function in Healthy Elderly—Resting State fMRI Study |
title_sort |
apathy and executive function in healthy elderly—resting state fmri study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2017-05-01 |
description |
Apathy is a quantitative reduction in goal-directed behaviors, having three subtypes. Despite executive deterioration in healthy aging, researchers have not investigated the “cognitive-deficit” subtype of apathy in healthy populations, which would result from executive dysfunction. We hypothesized that a relationship between apathy and executive function (EF) would be found in healthy older adults, accompanied with neural deterioration with functional dysconnectivity between the striatum and frontal region as suggested by previous studies. A total of 100 healthy adults in a health examination system database were analyzed. The present study indicates that apathy is substantially associated with executive deterioration, which can be partially ascribed to decreased functional connectivity between the frontal and ventral striatum. Despite some limitations, our findings may contribute to research on healthy psychological aging. |
topic |
age-related deterioration executive function cognitive apathy neuroimaging frontostriatal network |
url |
http://journal.frontiersin.org/article/10.3389/fnagi.2017.00124/full |
work_keys_str_mv |
AT toshikazukawagoe apathyandexecutivefunctioninhealthyelderlyrestingstatefmristudy AT keiichionoda apathyandexecutivefunctioninhealthyelderlyrestingstatefmristudy AT shuheiyamaguchi apathyandexecutivefunctioninhealthyelderlyrestingstatefmristudy |
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1725740847150923776 |