Metformin induces apoptosis and cell cycle arrest mediated by oxidative stress, AMPK and FOXO3a in MCF-7 breast cancer cells.

Metformin induces apoptosis and cell cycle arrest mediated by oxidative stress, AMPK and FOXO3a in MCF-7 breast cancer cells.

Recent studies have demonstrated that the anti-diabetic drug, metformin, can exhibit direct antitumoral effects, or can indirectly decrease tumor proliferation by improving insulin sensitivity. Despite these recent advances, the underlying molecular mechanisms involved in decreasing tumor formation...

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Bibliographic Details
Main Authors: Eveline A I F Queiroz, Stephanie Puukila, Rosangela Eichler, Sandra C Sampaio, Heidi L Forsyth, Simon J Lees, Aneli M Barbosa, Robert F H Dekker, Zuleica B Fortes, Neelam Khaper
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4032293?pdf=render

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