Cytokine and Chemokine Signals of T-Cell Exclusion in Tumors
The success of cancer immunotherapy in solid tumors depends on a sufficient distribution of effector T cells into malignant lesions. However, immune-cold tumors utilize many T-cell exclusion mechanisms to resist immunotherapy. T cells have to go through three steps to fight against tumors: trafficki...
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doaj-a9592720121b41b3885981913a545d032020-12-14T06:15:02ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-12-011110.3389/fimmu.2020.594609594609Cytokine and Chemokine Signals of T-Cell Exclusion in TumorsYu Zhang0Yu Zhang1Xin-yuan Guan2Peng Jiang3Cancer Data Science Lab, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United StatesDepartment of Clinical Oncology, University of Hong Kong, Hong Kong, Hong KongDepartment of Clinical Oncology, University of Hong Kong, Hong Kong, Hong KongCancer Data Science Lab, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United StatesThe success of cancer immunotherapy in solid tumors depends on a sufficient distribution of effector T cells into malignant lesions. However, immune-cold tumors utilize many T-cell exclusion mechanisms to resist immunotherapy. T cells have to go through three steps to fight against tumors: trafficking to the tumor core, surviving and expanding, and maintaining the memory phenotype for long-lasting responses. Cytokines and chemokines play critical roles in modulating the recruitment of T cells and the overall cellular compositions of the tumor microenvironment. Manipulating the cytokine or chemokine environment has brought success in preclinical models and early-stage clinical trials. However, depending on the immune context, the same cytokine or chemokine signals may exhibit either antitumor or protumor activities and induce unwanted side effects. Therefore, a comprehensive understanding of the cytokine and chemokine signals is the premise of overcoming T-cell exclusion for effective and innovative anti-cancer therapies.https://www.frontiersin.org/articles/10.3389/fimmu.2020.594609/fullT-cell exclusioncell therapyimmunotherapycytokinechemokine |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu Zhang Yu Zhang Xin-yuan Guan Peng Jiang |
spellingShingle |
Yu Zhang Yu Zhang Xin-yuan Guan Peng Jiang Cytokine and Chemokine Signals of T-Cell Exclusion in Tumors Frontiers in Immunology T-cell exclusion cell therapy immunotherapy cytokine chemokine |
author_facet |
Yu Zhang Yu Zhang Xin-yuan Guan Peng Jiang |
author_sort |
Yu Zhang |
title |
Cytokine and Chemokine Signals of T-Cell Exclusion in Tumors |
title_short |
Cytokine and Chemokine Signals of T-Cell Exclusion in Tumors |
title_full |
Cytokine and Chemokine Signals of T-Cell Exclusion in Tumors |
title_fullStr |
Cytokine and Chemokine Signals of T-Cell Exclusion in Tumors |
title_full_unstemmed |
Cytokine and Chemokine Signals of T-Cell Exclusion in Tumors |
title_sort |
cytokine and chemokine signals of t-cell exclusion in tumors |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2020-12-01 |
description |
The success of cancer immunotherapy in solid tumors depends on a sufficient distribution of effector T cells into malignant lesions. However, immune-cold tumors utilize many T-cell exclusion mechanisms to resist immunotherapy. T cells have to go through three steps to fight against tumors: trafficking to the tumor core, surviving and expanding, and maintaining the memory phenotype for long-lasting responses. Cytokines and chemokines play critical roles in modulating the recruitment of T cells and the overall cellular compositions of the tumor microenvironment. Manipulating the cytokine or chemokine environment has brought success in preclinical models and early-stage clinical trials. However, depending on the immune context, the same cytokine or chemokine signals may exhibit either antitumor or protumor activities and induce unwanted side effects. Therefore, a comprehensive understanding of the cytokine and chemokine signals is the premise of overcoming T-cell exclusion for effective and innovative anti-cancer therapies. |
topic |
T-cell exclusion cell therapy immunotherapy cytokine chemokine |
url |
https://www.frontiersin.org/articles/10.3389/fimmu.2020.594609/full |
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