Acute interstitial nephritis induced by Solanum nigrum

• Main Authors: Sung Sik Oh, Myung Woo Choi, Mi Rim Choi, Jong Hwa Lee, Hyun Ju Yang, Yeong Jin Choi, A Young Cho, Kwang Young Lee, In O Sun
• Format: Article
• Language: English
• Published: The Korean Society of Nephrology 2016-12-01
• Series: Kidney Research and Clinical Practice
• Subjects: Acute interstitial nephritis; Corticosteroid; Solanum
• Online Access: http://www.sciencedirect.com/science/article/pii/S2211913216300262

Acute interstitial nephritis (AIN) is an important cause of reversible acute kidney injury and pathologically characterized by inflammatory infiltrate in the renal interstitium. Solanum nigrum (S. nigrum) is a medicinal plant member of the Solanaceae family. Although S. nigrum has been traditionally used to treat various ailments such as pain, inflammation, and fever, it has also been reported to have a toxic effect, resulting in anticholinergic symptoms. However, there have been no reports of AIN caused by S. nigrum. Here, we report the first case of biopsy-confirmed AIN after ingestion of S. nigrum. The patient was successfully treated using corticosteroid therapy.