Plasma cell dyscrasia behavior in a referral hospital in southern Colombia: younger, clinically and paraclinically worse than reported
Objectives: Plasma cell dyscrasias are diseases characterized by clonal proliferation and accumulation of cells producing monoclonal immunoglobulins. These diseases have not been studied in our region and we don’t know if their behavior is similar to that reported in the literature. That’s why we ev...
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Sociedade Galega de Medicina Interna
2020-12-01
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doaj-a95bbd7c185d4ecda83a71497cb709ae2021-01-25T11:33:51ZengSociedade Galega de Medicina InternaGalicia Clínica0304-48661989-39222020-12-0181410210710.22546/58/19301930Plasma cell dyscrasia behavior in a referral hospital in southern Colombia: younger, clinically and paraclinically worse than reportedkenny buitrago-toroLuis Carlos Alvarez PerdomoLina Maria Leiva PanquevaAndres Felipe Mosquera ChavarroCarlos Perez Castañeda0Silvana Jimenez Salazar1North Side HospitalHospital Universitario Hernando Moncaleano PerdomoObjectives: Plasma cell dyscrasias are diseases characterized by clonal proliferation and accumulation of cells producing monoclonal immunoglobulins. These diseases have not been studied in our region and we don’t know if their behavior is similar to that reported in the literature. That’s why we evaluated multiple characteristics in southern Colombia. Methods: analytical cross-sectional study of patients with confirmed diagnosis of a plasma cell dyscrasias were included. Results: 60 patients included in our study, 65% were men, with an average age of 58.8 years (CI 96% 55.8 - 61.93). Bone pain was the most frequent symptom (88%). The most frequent dyscrasia was multiple myeloma and in these patients we found a high percentage of hemoglobin less than 10 mg/dl, creatinine greater than 2 mg/dl and serum calcium higher than 11 mg/dl (77%, 38% and 37 %, respectively). Half of the patients had a time course of symptoms greater than 4 months and 43% had plasma cells in bone marrow greater than 60%. 65% of patients had elevated levels of serum B2-microglobulin (> 5.5 mg/L) and in-hospital mortality was 15%. We found a statistically significant association between mortality and gender (PR 6.5) and between mortality and hemoglobin (p = 0.039). Conclusion: Patients with plasma cell dyscrasia in southern Colombia are younger, consult late, in an advanced stage of their disease, with greater renal damage, hypercalcemia and anemia than reported in the literature, also a high tumor burden due to high plasma cell infiltration into bone marrow and high values of serum B2-microglobulin.https://galiciaclinica.info/publicacion.asp?f=1930discrasias de células plasmáticasgamapatia monoclonalmieloma múltiplecarga tumoralcolombia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
kenny buitrago-toro Luis Carlos Alvarez Perdomo Lina Maria Leiva Panqueva Andres Felipe Mosquera Chavarro Carlos Perez Castañeda Silvana Jimenez Salazar |
spellingShingle |
kenny buitrago-toro Luis Carlos Alvarez Perdomo Lina Maria Leiva Panqueva Andres Felipe Mosquera Chavarro Carlos Perez Castañeda Silvana Jimenez Salazar Plasma cell dyscrasia behavior in a referral hospital in southern Colombia: younger, clinically and paraclinically worse than reported Galicia Clínica discrasias de células plasmáticas gamapatia monoclonal mieloma múltiple carga tumoral colombia |
author_facet |
kenny buitrago-toro Luis Carlos Alvarez Perdomo Lina Maria Leiva Panqueva Andres Felipe Mosquera Chavarro Carlos Perez Castañeda Silvana Jimenez Salazar |
author_sort |
kenny buitrago-toro |
title |
Plasma cell dyscrasia behavior in a referral hospital in southern Colombia: younger, clinically and paraclinically worse than reported |
title_short |
Plasma cell dyscrasia behavior in a referral hospital in southern Colombia: younger, clinically and paraclinically worse than reported |
title_full |
Plasma cell dyscrasia behavior in a referral hospital in southern Colombia: younger, clinically and paraclinically worse than reported |
title_fullStr |
Plasma cell dyscrasia behavior in a referral hospital in southern Colombia: younger, clinically and paraclinically worse than reported |
title_full_unstemmed |
Plasma cell dyscrasia behavior in a referral hospital in southern Colombia: younger, clinically and paraclinically worse than reported |
title_sort |
plasma cell dyscrasia behavior in a referral hospital in southern colombia: younger, clinically and paraclinically worse than reported |
publisher |
Sociedade Galega de Medicina Interna |
series |
Galicia Clínica |
issn |
0304-4866 1989-3922 |
publishDate |
2020-12-01 |
description |
Objectives: Plasma cell dyscrasias are diseases characterized by clonal proliferation and accumulation of cells producing monoclonal immunoglobulins. These diseases have not been studied in our region and we don’t know if their behavior is similar to that reported in the literature. That’s why we evaluated multiple characteristics in southern Colombia. Methods: analytical cross-sectional study of patients with confirmed diagnosis of a plasma cell dyscrasias were included. Results: 60 patients included in our study, 65% were men, with an average age of 58.8 years (CI 96% 55.8 - 61.93). Bone pain was the most frequent symptom (88%). The most frequent dyscrasia was multiple myeloma and in these patients we found a high percentage of hemoglobin less than 10 mg/dl, creatinine greater than 2 mg/dl and serum calcium higher than 11 mg/dl (77%, 38% and 37 %, respectively). Half of the patients had a time course of symptoms greater than 4 months and 43% had plasma cells in bone marrow greater than 60%. 65% of patients had elevated levels of serum B2-microglobulin (> 5.5 mg/L) and in-hospital mortality was 15%. We found a statistically significant association between mortality and gender (PR 6.5) and between mortality and hemoglobin (p = 0.039). Conclusion: Patients with plasma cell dyscrasia in southern Colombia are younger, consult late, in an advanced stage of their disease, with greater renal damage, hypercalcemia and anemia than reported in the literature, also a high tumor burden due to high plasma cell infiltration into bone marrow and high values of serum B2-microglobulin. |
topic |
discrasias de células plasmáticas gamapatia monoclonal mieloma múltiple carga tumoral colombia |
url |
https://galiciaclinica.info/publicacion.asp?f=1930 |
work_keys_str_mv |
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