Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis
Cellular senescence is characterised by the irreversible arrest of proliferation, a pro-inflammatory secretory phenotype and evasion of programmed cell death mechanisms. We report that senescence alters cellular iron acquisition and storage and also impedes iron-mediated cell death pathways. Senesce...
Main Authors: | Shashank Masaldan, Sharnel A.S. Clatworthy, Cristina Gamell, Peter M. Meggyesy, Antonia-Tonia Rigopoulos, Sue Haupt, Ygal Haupt, Delphine Denoyer, Paul A. Adlard, Ashley I. Bush, Michael A. Cater |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2018-04-01
|
Series: | Redox Biology |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231717306043 |
Similar Items
-
Copper accumulation in senescent cells: Interplay between copper transporters and impaired autophagy
by: Shashank Masaldan, et al.
Published: (2018-06-01) -
Ferritinophagy and ferroptosis in cardiovascular disease: Mechanisms and potential applications
by: Yuhan Qin, et al.
Published: (2021-09-01) -
Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis
by: Dominik C. Fuhrmann, et al.
Published: (2020-09-01) -
Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis
by: Chen, G., et al.
Published: (2022) -
Copper Ionophores as Novel Antiobesity Therapeutics
by: Peter M. Meggyesy, et al.
Published: (2020-10-01)