Rate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patients
Abstract Background The question of an age dependence of individual radiosensitivity has only marginally been studied so far. Therefore, we analyzed blood samples of healthy individuals and cancer patients of different ages to determine individual radiosensitivity. Methods Ex vivo irradiated blood s...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2018-05-01
|
Series: | BMC Geriatrics |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12877-018-0799-y |
id |
doaj-a9691a1ea76b4936b87a272466dc3375 |
---|---|
record_format |
Article |
spelling |
doaj-a9691a1ea76b4936b87a272466dc33752020-11-25T03:54:59ZengBMCBMC Geriatrics1471-23182018-05-011811810.1186/s12877-018-0799-yRate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patientsBarbara Schuster0Anna Ellmann1Theresa Mayo2Judith Auer3Matthias Haas4Markus Hecht5Rainer Fietkau6Luitpold V. Distel7Department of Radiation Oncology, University Hospital Erlangen Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Radiation Oncology, University Hospital Erlangen Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Radiation Oncology, University Hospital Erlangen Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Radiation Oncology, University Hospital Erlangen Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Radiology, Charité UniversitätsmedizinDepartment of Radiation Oncology, University Hospital Erlangen Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Radiation Oncology, University Hospital Erlangen Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Radiation Oncology, University Hospital Erlangen Friedrich-Alexander-Universität Erlangen-NürnbergAbstract Background The question of an age dependence of individual radiosensitivity has only marginally been studied so far. Therefore, we analyzed blood samples of healthy individuals and cancer patients of different ages to determine individual radiosensitivity. Methods Ex vivo irradiated blood samples of 595 individuals were tested. Chromosomes 1, 2 and 4 were stained by 3-color fluorescence in situ hybridization and aberrations were analyzed. Radiosensitivity was determined by the mean breaks per metaphase (B/M). Results Healthy individuals (mean age 50.7 years) had an average B/M value of 0.42 ± 0.104 and an increase of 0.0014B/M per year. The patients (mean age 60.4 years) had an average B/M value of 0.44 ± 0.150 and radiosensitivity did not change with age. In previous studies we found that from a value of 0.6B/M on an individual is considered to be distinctly radiosensitive. The portion of radiosensitive individuals (B/M > 0.6) increased in both cohorts with age. Conclusion Individual radiosensitivity rises continuously with age, yet with strong interindividual variation. No age related increase of radiosensitivity can be demonstrated in patients due to the strong interindividual variation. However among old cancer patients there is a higher probability to have patients with clearly increased radiosensitivity than at younger age.http://link.springer.com/article/10.1186/s12877-018-0799-yRadiosensitivity3-colour fluorescence in situ hybridizationChromosomal aberrationBreaks per metaphaseIndividual radiosensitivity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Barbara Schuster Anna Ellmann Theresa Mayo Judith Auer Matthias Haas Markus Hecht Rainer Fietkau Luitpold V. Distel |
spellingShingle |
Barbara Schuster Anna Ellmann Theresa Mayo Judith Auer Matthias Haas Markus Hecht Rainer Fietkau Luitpold V. Distel Rate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patients BMC Geriatrics Radiosensitivity 3-colour fluorescence in situ hybridization Chromosomal aberration Breaks per metaphase Individual radiosensitivity |
author_facet |
Barbara Schuster Anna Ellmann Theresa Mayo Judith Auer Matthias Haas Markus Hecht Rainer Fietkau Luitpold V. Distel |
author_sort |
Barbara Schuster |
title |
Rate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patients |
title_short |
Rate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patients |
title_full |
Rate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patients |
title_fullStr |
Rate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patients |
title_full_unstemmed |
Rate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patients |
title_sort |
rate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patients |
publisher |
BMC |
series |
BMC Geriatrics |
issn |
1471-2318 |
publishDate |
2018-05-01 |
description |
Abstract Background The question of an age dependence of individual radiosensitivity has only marginally been studied so far. Therefore, we analyzed blood samples of healthy individuals and cancer patients of different ages to determine individual radiosensitivity. Methods Ex vivo irradiated blood samples of 595 individuals were tested. Chromosomes 1, 2 and 4 were stained by 3-color fluorescence in situ hybridization and aberrations were analyzed. Radiosensitivity was determined by the mean breaks per metaphase (B/M). Results Healthy individuals (mean age 50.7 years) had an average B/M value of 0.42 ± 0.104 and an increase of 0.0014B/M per year. The patients (mean age 60.4 years) had an average B/M value of 0.44 ± 0.150 and radiosensitivity did not change with age. In previous studies we found that from a value of 0.6B/M on an individual is considered to be distinctly radiosensitive. The portion of radiosensitive individuals (B/M > 0.6) increased in both cohorts with age. Conclusion Individual radiosensitivity rises continuously with age, yet with strong interindividual variation. No age related increase of radiosensitivity can be demonstrated in patients due to the strong interindividual variation. However among old cancer patients there is a higher probability to have patients with clearly increased radiosensitivity than at younger age. |
topic |
Radiosensitivity 3-colour fluorescence in situ hybridization Chromosomal aberration Breaks per metaphase Individual radiosensitivity |
url |
http://link.springer.com/article/10.1186/s12877-018-0799-y |
work_keys_str_mv |
AT barbaraschuster rateofindividualswithclearlyincreasedradiosensitivityrisewithagebothinhealthyindividualsandincancerpatients AT annaellmann rateofindividualswithclearlyincreasedradiosensitivityrisewithagebothinhealthyindividualsandincancerpatients AT theresamayo rateofindividualswithclearlyincreasedradiosensitivityrisewithagebothinhealthyindividualsandincancerpatients AT judithauer rateofindividualswithclearlyincreasedradiosensitivityrisewithagebothinhealthyindividualsandincancerpatients AT matthiashaas rateofindividualswithclearlyincreasedradiosensitivityrisewithagebothinhealthyindividualsandincancerpatients AT markushecht rateofindividualswithclearlyincreasedradiosensitivityrisewithagebothinhealthyindividualsandincancerpatients AT rainerfietkau rateofindividualswithclearlyincreasedradiosensitivityrisewithagebothinhealthyindividualsandincancerpatients AT luitpoldvdistel rateofindividualswithclearlyincreasedradiosensitivityrisewithagebothinhealthyindividualsandincancerpatients |
_version_ |
1724471356817408000 |