Antidiarrhoeal activity of leaf extract of Celosia Argentea in experimentally induced diarrhoea in rats

• Main Authors: Praveen Sharma, Gali Vidyasagar, Sunder Singh, Santosh Ghule, Bimlesh Kumar
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2010-01-01
• Series: Journal of Advanced Pharmaceutical Technology & Research
• Subjects: Celosia argentea; castor oil diarrhoea; charcoal meal; PGE 2
• Online Access: http://www.japtr.org/article.asp?issn=2231-4040;year=2010;volume=1;issue=1;spage=41;epage=48;aulast=Sharma

In order to scientifically apprise some of the anecdotal, folkloric, ethno medical uses of celosia argentea, the present study was undertaken to examine the antidiarrhoeal properties of alcoholic extract of leaves of Celosia argentea on diarrhoea by using different experimental models. Anti-diarrhoeal effect was evaluated by castor oil induced diarrhoea, charcoal meal test and PGE 2 induced diarrhoea. Loperamide (2 mg/kg) and atropine (0.1mg/kg) were used as standard drugs. Extract was used in 100 and 200 mg/kg dose. It produced dose related anti-diarrhoeal effect. Results suggest that it may act centrally and may inhibit the PGE2 to give anti-diarrhoeal effects. Result of charcoal meal test also suggests its anti-muscarinic activity.