Glucose Concentration in Cell Culture Medium Influences the BRCA1-Mediated Regulation of the Lipogenic Action of IGF-I in Breast Cancer Cells

Glucose Concentration in Cell Culture Medium Influences the BRCA1-Mediated Regulation of the Lipogenic Action of IGF-I in Breast Cancer Cells

Hyperglycaemia is a common metabolic alteration associated with breast cancer risk and progression. We have previously reported that BRCA1 restrains metabolic activity and proliferative response to IGF-I anabolic actions in breast cancer cells cultured in high glucose. Here, we evaluated the impact...

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Bibliographic Details
Main Authors: Moses O. Koobotse, Dayane Schmidt, Jeff M. P. Holly, Claire M. Perks
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
hyperglycaemia
BRCA1
IGF-I
fatty acid synthesis
breast cancer
Online Access:https://www.mdpi.com/1422-0067/21/22/8674

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