Glomerular Filtration Rate Estimation Based on Cystatin C Formulas among Neonates
Background: Glomerular filtration rate (GFR) is the best indicator to assess renal function; however, it is difficult to perform it, especially in neonates. Serum creatinine is the most commonly used marker of GFR; nevertheless, it has some limitations since it can be affected by factors other than...
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Mashhad University of Medical Sciences
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doaj-a9793374a6784440863b9297334dc6382021-08-02T21:00:55ZengMashhad University of Medical SciencesIranian Journal of Neonatology2251-75102322-21582021-04-01122212610.22038/ijn.2021.43684.172717381Glomerular Filtration Rate Estimation Based on Cystatin C Formulas among NeonatesNasrin Khalesi0Farnoosh Seirafianpour1Rozita Hoseini2Hassan Otukesh3Nahid Rahimzadeh4Shahrbanoo Nakhaie5Golnar Gohardehi6Parisa Mohaghegh7Iran University of Medical Sciences, Tehran, IranStudent Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, IranIran University of Medical Sciences, Tehran, IranIran University of Medical Sciences, Tehran, IranIran University of Medical Sciences, Tehran, IranIran University of Medical Sciences, Tehran, IranIran University of Medical Sciences, Tehran, IranIran University of Medical Sciences, Tehran, IranBackground: Glomerular filtration rate (GFR) is the best indicator to assess renal function; however, it is difficult to perform it, especially in neonates. Serum creatinine is the most commonly used marker of GFR; nevertheless, it has some limitations since it can be affected by factors other than renal function. Cystatin C, another endogenous marker used to estimate GFR, is not affected by non-renal factors. The results of some studies suggest that serum cystatin C levels are more accurate tests of kidney function than serum creatinine levels. This study aimed to estimate GFR with cystatin C-based formulas among neonates and determine the correlations between these methods and the Schwartz formula. Methods: The population of this research consisted of 99 neonates whose serum creatinine and cystatin C levels were measured concurrently. Moreover, the glomerular filtration rate was estimated using the Schwartz formula and 14 cystatin C-based formulas separately. Results: Based on the findings, all GFR values based on cystatin C formulas correlated significantly with each other (p <0.05); however, with one exception, none of these values correlated with Schwartz GFR (P>0.05). The only cystatin C formula that yielded values correlating with the Schwartz formula was CysCrEq, which used serum cystatin C and creatinine concomitantly. Conclusion: It can be concluded that since all GFR values based on cystatin C correlated significantly and cystatin Cwasindependent of non-renal factors, cystatin C reflected the real GFR more accurately than serum creatinine. Nonetheless, further studies with gold standard techniques are required to verify the usefulness of cystatin C-based formulas.https://ijn.mums.ac.ir/article_17381_ea6136eba39b2a3e42efa60e6ffeb035.pdfcreatinineglomerular filtration rateneonatesschwartz formula |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nasrin Khalesi Farnoosh Seirafianpour Rozita Hoseini Hassan Otukesh Nahid Rahimzadeh Shahrbanoo Nakhaie Golnar Gohardehi Parisa Mohaghegh |
spellingShingle |
Nasrin Khalesi Farnoosh Seirafianpour Rozita Hoseini Hassan Otukesh Nahid Rahimzadeh Shahrbanoo Nakhaie Golnar Gohardehi Parisa Mohaghegh Glomerular Filtration Rate Estimation Based on Cystatin C Formulas among Neonates Iranian Journal of Neonatology creatinine glomerular filtration rate neonates schwartz formula |
author_facet |
Nasrin Khalesi Farnoosh Seirafianpour Rozita Hoseini Hassan Otukesh Nahid Rahimzadeh Shahrbanoo Nakhaie Golnar Gohardehi Parisa Mohaghegh |
author_sort |
Nasrin Khalesi |
title |
Glomerular Filtration Rate Estimation Based on Cystatin C Formulas among Neonates |
title_short |
Glomerular Filtration Rate Estimation Based on Cystatin C Formulas among Neonates |
title_full |
Glomerular Filtration Rate Estimation Based on Cystatin C Formulas among Neonates |
title_fullStr |
Glomerular Filtration Rate Estimation Based on Cystatin C Formulas among Neonates |
title_full_unstemmed |
Glomerular Filtration Rate Estimation Based on Cystatin C Formulas among Neonates |
title_sort |
glomerular filtration rate estimation based on cystatin c formulas among neonates |
publisher |
Mashhad University of Medical Sciences |
series |
Iranian Journal of Neonatology |
issn |
2251-7510 2322-2158 |
publishDate |
2021-04-01 |
description |
Background: Glomerular filtration rate (GFR) is the best indicator to assess renal function; however, it is difficult to perform it, especially in neonates. Serum creatinine is the most commonly used marker of GFR; nevertheless, it has some limitations since it can be affected by factors other than renal function. Cystatin C, another endogenous marker used to estimate GFR, is not affected by non-renal factors. The results of some studies suggest that serum cystatin C levels are more accurate tests of kidney function than serum creatinine levels. This study aimed to estimate GFR with cystatin C-based formulas among neonates and determine the correlations between these methods and the Schwartz formula. Methods: The population of this research consisted of 99 neonates whose serum creatinine and cystatin C levels were measured concurrently. Moreover, the glomerular filtration rate was estimated using the Schwartz formula and 14 cystatin C-based formulas separately. Results: Based on the findings, all GFR values based on cystatin C formulas correlated significantly with each other (p <0.05); however, with one exception, none of these values correlated with Schwartz GFR (P>0.05). The only cystatin C formula that yielded values correlating with the Schwartz formula was CysCrEq, which used serum cystatin C and creatinine concomitantly. Conclusion: It can be concluded that since all GFR values based on cystatin C correlated significantly and cystatin Cwasindependent of non-renal factors, cystatin C reflected the real GFR more accurately than serum creatinine. Nonetheless, further studies with gold standard techniques are required to verify the usefulness of cystatin C-based formulas. |
topic |
creatinine glomerular filtration rate neonates schwartz formula |
url |
https://ijn.mums.ac.ir/article_17381_ea6136eba39b2a3e42efa60e6ffeb035.pdf |
work_keys_str_mv |
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