PRP-19, a conserved pre-mRNA processing factor and E3 ubiquitin ligase, inhibits the nuclear accumulation of GLP-1/Notch intracellular domain

PRP-19, a conserved pre-mRNA processing factor and E3 ubiquitin ligase, inhibits the nuclear accumulation of GLP-1/Notch intracellular domain

The Notch signalling pathway is a conserved and widespread signalling paradigm, and its misregulation has been implicated in numerous disorders, including cancer. The output of Notch signalling depends on the nuclear accumulation of the Notch receptor intracellular domain (ICD). Using the Caenorhabd...

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Bibliographic Details
Main Authors: Silvia Gutnik, Yann Thomas, Yanwu Guo, Janosch Stoecklin, Anca Neagu, Lionel Pintard, Jorge Merlet, Rafal Ciosk
Format: Article
Language:English
Published: The Company of Biologists 2018-07-01
Series:Biology Open
Subjects:
Caenorhabditis elegans
GLP-1
Notch
PRP-19
Splicing
Ubiquitin ligase
Online Access:http://bio.biologists.org/content/7/7/bio034066

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