Genome-wide association meta-analysis yields 20 loci associated with gallstone disease

Genome-wide association studies have so far identified eight risk loci for gallstone disease. Here, the authors perform meta-analysis in cohorts from Iceland and the UK which reveals further 21 common and low-frequency risk variants that highlight the role of bile acid homeostasis in gallstone disea...

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Main Authors:	Egil Ferkingstad, Asmundur Oddsson, Solveig Gretarsdottir, Stefania Benonisdottir, Gudmar Thorleifsson, Aimee M. Deaton, Stefan Jonsson, Olafur A. Stefansson, Gudmundur L. Norddahl, Florian Zink, Gudny A. Arnadottir, Bjarni Gunnarsson, Gisli H. Halldorsson, Anna Helgadottir, Brynjar O. Jensson, Ragnar P. Kristjansson, Gardar Sveinbjornsson, David A. Sverrisson, Gisli Masson, Isleifur Olafsson, Gudmundur I. Eyjolfsson, Olof Sigurdardottir, Hilma Holm, Ingileif Jonsdottir, Sigurdur Olafsson, Thora Steingrimsdottir, Thorunn Rafnar, Einar S. Bjornsson, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Patrick Sulem, Kari Stefansson
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-07460-y

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spelling	doaj-a99d2484d9a048f3ab41a8a1d889ba682021-05-11T10:15:46ZengNature Publishing GroupNature Communications2041-17232018-11-019111110.1038/s41467-018-07460-yGenome-wide association meta-analysis yields 20 loci associated with gallstone diseaseEgil Ferkingstad0Asmundur Oddsson1Solveig Gretarsdottir2Stefania Benonisdottir3Gudmar Thorleifsson4Aimee M. Deaton5Stefan Jonsson6Olafur A. Stefansson7Gudmundur L. Norddahl8Florian Zink9Gudny A. Arnadottir10Bjarni Gunnarsson11Gisli H. Halldorsson12Anna Helgadottir13Brynjar O. Jensson14Ragnar P. Kristjansson15Gardar Sveinbjornsson16David A. Sverrisson17Gisli Masson18Isleifur Olafsson19Gudmundur I. Eyjolfsson20Olof Sigurdardottir21Hilma Holm22Ingileif Jonsdottir23Sigurdur Olafsson24Thora Steingrimsdottir25Thorunn Rafnar26Einar S. Bjornsson27Unnur Thorsteinsdottir28Daniel F. Gudbjartsson29Patrick Sulem30Kari Stefansson31deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.Department of Clinical Biochemistry, Landspítali University HospitalLaboratory in Mjódd (RAM)Department of Clinical Biochemistry, Akureyri HospitaldeCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.Department of Internal Medicine, Landspitali University HospitalFaculty of Medicine, University of IcelanddeCODE Genetics/Amgen, Inc.Faculty of Medicine, University of IcelanddeCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.Genome-wide association studies have so far identified eight risk loci for gallstone disease. Here, the authors perform meta-analysis in cohorts from Iceland and the UK which reveals further 21 common and low-frequency risk variants that highlight the role of bile acid homeostasis in gallstone disease.https://doi.org/10.1038/s41467-018-07460-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Egil Ferkingstad Asmundur Oddsson Solveig Gretarsdottir Stefania Benonisdottir Gudmar Thorleifsson Aimee M. Deaton Stefan Jonsson Olafur A. Stefansson Gudmundur L. Norddahl Florian Zink Gudny A. Arnadottir Bjarni Gunnarsson Gisli H. Halldorsson Anna Helgadottir Brynjar O. Jensson Ragnar P. Kristjansson Gardar Sveinbjornsson David A. Sverrisson Gisli Masson Isleifur Olafsson Gudmundur I. Eyjolfsson Olof Sigurdardottir Hilma Holm Ingileif Jonsdottir Sigurdur Olafsson Thora Steingrimsdottir Thorunn Rafnar Einar S. Bjornsson Unnur Thorsteinsdottir Daniel F. Gudbjartsson Patrick Sulem Kari Stefansson
spellingShingle	Egil Ferkingstad Asmundur Oddsson Solveig Gretarsdottir Stefania Benonisdottir Gudmar Thorleifsson Aimee M. Deaton Stefan Jonsson Olafur A. Stefansson Gudmundur L. Norddahl Florian Zink Gudny A. Arnadottir Bjarni Gunnarsson Gisli H. Halldorsson Anna Helgadottir Brynjar O. Jensson Ragnar P. Kristjansson Gardar Sveinbjornsson David A. Sverrisson Gisli Masson Isleifur Olafsson Gudmundur I. Eyjolfsson Olof Sigurdardottir Hilma Holm Ingileif Jonsdottir Sigurdur Olafsson Thora Steingrimsdottir Thorunn Rafnar Einar S. Bjornsson Unnur Thorsteinsdottir Daniel F. Gudbjartsson Patrick Sulem Kari Stefansson Genome-wide association meta-analysis yields 20 loci associated with gallstone disease Nature Communications
author_facet	Egil Ferkingstad Asmundur Oddsson Solveig Gretarsdottir Stefania Benonisdottir Gudmar Thorleifsson Aimee M. Deaton Stefan Jonsson Olafur A. Stefansson Gudmundur L. Norddahl Florian Zink Gudny A. Arnadottir Bjarni Gunnarsson Gisli H. Halldorsson Anna Helgadottir Brynjar O. Jensson Ragnar P. Kristjansson Gardar Sveinbjornsson David A. Sverrisson Gisli Masson Isleifur Olafsson Gudmundur I. Eyjolfsson Olof Sigurdardottir Hilma Holm Ingileif Jonsdottir Sigurdur Olafsson Thora Steingrimsdottir Thorunn Rafnar Einar S. Bjornsson Unnur Thorsteinsdottir Daniel F. Gudbjartsson Patrick Sulem Kari Stefansson
author_sort	Egil Ferkingstad
title	Genome-wide association meta-analysis yields 20 loci associated with gallstone disease
title_short	Genome-wide association meta-analysis yields 20 loci associated with gallstone disease
title_full	Genome-wide association meta-analysis yields 20 loci associated with gallstone disease
title_fullStr	Genome-wide association meta-analysis yields 20 loci associated with gallstone disease
title_full_unstemmed	Genome-wide association meta-analysis yields 20 loci associated with gallstone disease
title_sort	genome-wide association meta-analysis yields 20 loci associated with gallstone disease
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-11-01
description	Genome-wide association studies have so far identified eight risk loci for gallstone disease. Here, the authors perform meta-analysis in cohorts from Iceland and the UK which reveals further 21 common and low-frequency risk variants that highlight the role of bile acid homeostasis in gallstone disease.
url	https://doi.org/10.1038/s41467-018-07460-y
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Genome-wide association meta-analysis yields 20 loci associated with gallstone disease

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