Elevated Expression of MiR-17 in Microglia of Alzheimer’s Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation

Elevated Expression of MiR-17 in Microglia of Alzheimer’s Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation

Autophagy is a proposed route of amyloid-β (Aβ) clearance by microglia that is halted in Alzheimer’s Disease (AD), though mechanisms underlying this dysfunction remain elusive. Here, primary microglia from adult AD (5xFAD) mice were utilized to demonstrate that 5xFAD microglia fail to degrade Aβ and...

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Main Authors: Shady Estfanous, Kylene P. Daily, Mostafa Eltobgy, Nicholas P. Deems, Midhun N. K. Anne, Kathrin Krause, Asmaa Badr, Kaitlin Hamilton, Cierra Carafice, Ahmad Hegazi, Arwa Abu Khweek, Hesham Kelani, Shahid Nimjee, Hamdy Awad, Xiaoli Zhang, Estelle Cormet-Boyaka, Hesham Haffez, Sameh Soror, Adel Mikhail, Gerard Nuovo, Ruth M. Barrientos, Mikhail A. Gavrilin, Amal O. Amer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
autophagy
microglia
NBR1
microRNA
Amyloid-β
Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.705581/full

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