Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer

Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer

Active epidermal growth factor receptors (EGFR) signaling mediates the progression of colorectal cancer (CRC) through activation of downstream kinases and transcription factors. The increased expression of EGFR was associated with worse prognosis in patients with metastatic CRC (mCRC). Regorafenib,...

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Bibliographic Details
Main Authors: Yu-Chang Liu, Jai-Jen Tsai, Yueh-Shan Weng, Fei-Ting Hsu
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Regorafenib
Epidermal growth factor receptors
PKC-δ
NF-κB
Colon rectal cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220305114

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