Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet
We show that hypercholesterolemia contributes to oxidative stress injury progression in brain and simvastatin counteracts the cholesterol-induced peroxidation injury in rabbit hippocampus, and we demonstrate for the first time that the simvastatin is a critical role in brain protection and identify...
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2016-01-01
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Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2016/6929306 |
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doaj-a9ce1915cf114da09debcec040f217a22020-11-24T22:21:41ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942016-01-01201610.1155/2016/69293066929306Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol DietGuangyin Zhang0Ming Li1Yinzhi Xu2Li Peng3Cui Yang4Yanan Zhou5Junping Zhang6Department of Psychosomatic, First Teaching Hospital of Tianjin University of TCM, Tianjin 300193, ChinaDepartment of Cardiology, First Teaching Hospital of Tianjin University of TCM, Tianjin 300193, ChinaDepartment of Geriatrics, First Teaching Hospital of Tianjin University of TCM, Tianjin 300193, ChinaTianjin University of Traditional Chinese Medicine, Tianjin 300193, ChinaTianjin University of Traditional Chinese Medicine, Tianjin 300193, ChinaTianjin University of Traditional Chinese Medicine, Tianjin 300193, ChinaFirst Teaching Hospital of Tianjin University of TCM, Room 309, Office Building, No. 314, An Shan Xi Road, Nankai District, Tianjin 300193, ChinaWe show that hypercholesterolemia contributes to oxidative stress injury progression in brain and simvastatin counteracts the cholesterol-induced peroxidation injury in rabbit hippocampus, and we demonstrate for the first time that the simvastatin is a critical role in brain protection and identify HO-1 and other related antioxidant enzymes as molecular target for active redox compounds. Second, our experiments have pointed out an association between statin treatment and a decrease in the risk of having peroxidation damage of brain. The balance effects of simvastatin to ROS and antioxidants enzymes network are most probably due to improved SOD functional activity, increase in GSH-Px, increase in HO-1 expression, and decrease of MDA generation.http://dx.doi.org/10.1155/2016/6929306 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guangyin Zhang Ming Li Yinzhi Xu Li Peng Cui Yang Yanan Zhou Junping Zhang |
spellingShingle |
Guangyin Zhang Ming Li Yinzhi Xu Li Peng Cui Yang Yanan Zhou Junping Zhang Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet Oxidative Medicine and Cellular Longevity |
author_facet |
Guangyin Zhang Ming Li Yinzhi Xu Li Peng Cui Yang Yanan Zhou Junping Zhang |
author_sort |
Guangyin Zhang |
title |
Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet |
title_short |
Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet |
title_full |
Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet |
title_fullStr |
Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet |
title_full_unstemmed |
Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet |
title_sort |
antioxidation effect of simvastatin in aorta and hippocampus: a rabbit model fed high-cholesterol diet |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2016-01-01 |
description |
We show that hypercholesterolemia contributes to oxidative stress injury progression in brain and simvastatin counteracts the cholesterol-induced peroxidation injury in rabbit hippocampus, and we demonstrate for the first time that the simvastatin is a critical role in brain protection and identify HO-1 and other related antioxidant enzymes as molecular target for active redox compounds. Second, our experiments have pointed out an association between statin treatment and a decrease in the risk of having peroxidation damage of brain. The balance effects of simvastatin to ROS and antioxidants enzymes network are most probably due to improved SOD functional activity, increase in GSH-Px, increase in HO-1 expression, and decrease of MDA generation. |
url |
http://dx.doi.org/10.1155/2016/6929306 |
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