Use of fecal volatile organic compound analysis to discriminate between non-vaccinated and BCG-Vaccinated cattle prior to and after Mycobacterium bovis challenge.

Bovine tuberculosis is a zoonotic disease of global public health concern. Development of diagnostic tools to improve test accuracy and efficiency in domestic livestock and enable surveillance of wildlife reservoirs would improve disease management and eradication efforts. Use of volatile organic co...

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Main Authors:	Christine K Ellis, Somchai Rice, Devin Maurer, Randal Stahl, W Ray Waters, Mitchell V Palmer, Pauline Nol, Jack C Rhyan, Kurt C VerCauteren, Jacek A Koziel
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2017-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC5501492?pdf=render

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spelling	doaj-a9d609275360462d847c5c5a5124cc292020-11-25T01:46:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01127e017991410.1371/journal.pone.0179914Use of fecal volatile organic compound analysis to discriminate between non-vaccinated and BCG-Vaccinated cattle prior to and after Mycobacterium bovis challenge.Christine K EllisSomchai RiceDevin MaurerRandal StahlW Ray WatersMitchell V PalmerPauline NolJack C RhyanKurt C VerCauterenJacek A KozielBovine tuberculosis is a zoonotic disease of global public health concern. Development of diagnostic tools to improve test accuracy and efficiency in domestic livestock and enable surveillance of wildlife reservoirs would improve disease management and eradication efforts. Use of volatile organic compound analysis in breath and fecal samples is being developed and optimized as a means to detect disease in humans and animals. In this study we demonstrate that VOCs present in fecal samples can be used to discriminate between non-vaccinated and BCG-vaccinated cattle prior to and after Mycobacterium bovis challenge.http://europepmc.org/articles/PMC5501492?pdf=render
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Christine K Ellis Somchai Rice Devin Maurer Randal Stahl W Ray Waters Mitchell V Palmer Pauline Nol Jack C Rhyan Kurt C VerCauteren Jacek A Koziel
spellingShingle	Christine K Ellis Somchai Rice Devin Maurer Randal Stahl W Ray Waters Mitchell V Palmer Pauline Nol Jack C Rhyan Kurt C VerCauteren Jacek A Koziel Use of fecal volatile organic compound analysis to discriminate between non-vaccinated and BCG-Vaccinated cattle prior to and after Mycobacterium bovis challenge. PLoS ONE
author_facet	Christine K Ellis Somchai Rice Devin Maurer Randal Stahl W Ray Waters Mitchell V Palmer Pauline Nol Jack C Rhyan Kurt C VerCauteren Jacek A Koziel
author_sort	Christine K Ellis
title	Use of fecal volatile organic compound analysis to discriminate between non-vaccinated and BCG-Vaccinated cattle prior to and after Mycobacterium bovis challenge.
title_short	Use of fecal volatile organic compound analysis to discriminate between non-vaccinated and BCG-Vaccinated cattle prior to and after Mycobacterium bovis challenge.
title_full	Use of fecal volatile organic compound analysis to discriminate between non-vaccinated and BCG-Vaccinated cattle prior to and after Mycobacterium bovis challenge.
title_fullStr	Use of fecal volatile organic compound analysis to discriminate between non-vaccinated and BCG-Vaccinated cattle prior to and after Mycobacterium bovis challenge.
title_full_unstemmed	Use of fecal volatile organic compound analysis to discriminate between non-vaccinated and BCG-Vaccinated cattle prior to and after Mycobacterium bovis challenge.
title_sort	use of fecal volatile organic compound analysis to discriminate between non-vaccinated and bcg-vaccinated cattle prior to and after mycobacterium bovis challenge.
publisher	Public Library of Science (PLoS)
series	PLoS ONE
issn	1932-6203
publishDate	2017-01-01
description	Bovine tuberculosis is a zoonotic disease of global public health concern. Development of diagnostic tools to improve test accuracy and efficiency in domestic livestock and enable surveillance of wildlife reservoirs would improve disease management and eradication efforts. Use of volatile organic compound analysis in breath and fecal samples is being developed and optimized as a means to detect disease in humans and animals. In this study we demonstrate that VOCs present in fecal samples can be used to discriminate between non-vaccinated and BCG-vaccinated cattle prior to and after Mycobacterium bovis challenge.
url	http://europepmc.org/articles/PMC5501492?pdf=render
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Use of fecal volatile organic compound analysis to discriminate between non-vaccinated and BCG-Vaccinated cattle prior to and after Mycobacterium bovis challenge.

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