Chrysin and its potential antineoplastic effect

• Main Authors: Patrycja Chylińska-Wrzos, Marta Lis-Sochocka, Barbara Jodłowska-Jędrych
• Format: Article
• Language: English
• Published: TMKarpinski Publisher, Tomasz M. Karpiński 2017-09-01
• Series: European Journal of Biological Research
• Subjects: Chrysin; Flavonoids; Propolis; Anticancer activity
• Online Access: http://www.journals.tmkarpinski.com/index.php/ejbr/article/view/171

In 2012, in Europe, there were noticed over 3 million new cases of cancer and 1.75 million of deaths from cancer. Numerous anticancer agents are cytotoxic, can damage normal cells, and they can cause serious side effects. Currently, natural and non-toxic agents are being sought that reduce the cost of therapy, are more effective and targeted, and do not damage healthy cells. Chrysin which belong to flavonoids family as natural substance, has multiple anticancer activities. It has been reported that chrysin can induce apoptosis in tumour cells by different mechanism. In our work we demonstrated the potential use of chrysin in gastrointestinal, breast, cervical, and lung cancer. In conclusion it is proven that chrysin or combination of chrysin with other related drugs can effectively improve the effectiveness of anticancer therapy. Furthermore, new agents, such as nanoparticles, may show greater efficacy, and better targeting, hence, less side effects on healthy cells. Based on these results, nanochrysin it offers as new and effective drug delivery system. Moreover, it has been reported that chrysin is a potential antitumor but also an adjuvant agent that can be used in combination with other antimetastatic substances to reduce tumor metastasis. DOI: http://dx.doi.org/10.5281/zenodo.844470