Gain of Function for the SCN1A/hNav1.1-L1670W Mutation Responsible for Familial Hemiplegic Migraine

Gain of Function for the SCN1A/hNav1.1-L1670W Mutation Responsible for Familial Hemiplegic Migraine

The SCN1A gene encodes for the voltage-dependent Nav1.1 Na+ channel, an isoform mainly expressed in GABAergic neurons that is the target of hundreds of epileptogenic mutations. More recently, it has been shown that the SCN1A gene is also the target of mutations responsible for familial hemiplegic mi...

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Bibliographic Details
Main Authors: Sandra Dhifallah, Eric Lancaster, Shana Merrill, Nathalie Leroudier, Massimo Mantegazza, Sandrine Cestèle
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
migraine with aura
sodium channels
GABAergic neurons
cortical spreading depression
epilepsy
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00232/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00232/full

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