Lab-on-a-Chip for Cardiovascular Physiology and Pathology
Lab-on-a-chip technologies have allowed researchers to acquire a flexible, yet relatively inexpensive testbed to study one of the leading causes of death worldwide, cardiovascular disease. Cardiovascular diseases, such as peripheral artery disease, arteriosclerosis, and aortic stenosis, for example,...
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doaj-a9f049ca44e34138b384f56f22f232b02020-11-25T01:38:56ZengMDPI AGMicromachines2072-666X2020-09-011189889810.3390/mi11100898Lab-on-a-Chip for Cardiovascular Physiology and PathologySean Beverung0Jingwen Wu1Robert Steward2Department of Mechanical and Aerospace Engineering, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USADepartment of Mechanical and Aerospace Engineering, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USADepartment of Mechanical and Aerospace Engineering, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USALab-on-a-chip technologies have allowed researchers to acquire a flexible, yet relatively inexpensive testbed to study one of the leading causes of death worldwide, cardiovascular disease. Cardiovascular diseases, such as peripheral artery disease, arteriosclerosis, and aortic stenosis, for example, have all been studied by lab-on-a-chip technologies. These technologies allow for the integration of mammalian cells into functional structures that mimic vital organs with geometries comparable to those found in vivo. For this review, we focus on microdevices that have been developed to study cardiovascular physiology and pathology. With these technologies, researchers can better understand the electrical–biomechanical properties unique to cardiomyocytes and better stimulate and understand the influence of blood flow on the human vasculature. Such studies have helped increase our understanding of many cardiovascular diseases in general; as such, we present here a review of the current state of the field and potential for the future.https://www.mdpi.com/2072-666X/11/10/898lab-on-a-chipcardiovascular diseasemicrofluidicscell culture |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sean Beverung Jingwen Wu Robert Steward |
spellingShingle |
Sean Beverung Jingwen Wu Robert Steward Lab-on-a-Chip for Cardiovascular Physiology and Pathology Micromachines lab-on-a-chip cardiovascular disease microfluidics cell culture |
author_facet |
Sean Beverung Jingwen Wu Robert Steward |
author_sort |
Sean Beverung |
title |
Lab-on-a-Chip for Cardiovascular Physiology and Pathology |
title_short |
Lab-on-a-Chip for Cardiovascular Physiology and Pathology |
title_full |
Lab-on-a-Chip for Cardiovascular Physiology and Pathology |
title_fullStr |
Lab-on-a-Chip for Cardiovascular Physiology and Pathology |
title_full_unstemmed |
Lab-on-a-Chip for Cardiovascular Physiology and Pathology |
title_sort |
lab-on-a-chip for cardiovascular physiology and pathology |
publisher |
MDPI AG |
series |
Micromachines |
issn |
2072-666X |
publishDate |
2020-09-01 |
description |
Lab-on-a-chip technologies have allowed researchers to acquire a flexible, yet relatively inexpensive testbed to study one of the leading causes of death worldwide, cardiovascular disease. Cardiovascular diseases, such as peripheral artery disease, arteriosclerosis, and aortic stenosis, for example, have all been studied by lab-on-a-chip technologies. These technologies allow for the integration of mammalian cells into functional structures that mimic vital organs with geometries comparable to those found in vivo. For this review, we focus on microdevices that have been developed to study cardiovascular physiology and pathology. With these technologies, researchers can better understand the electrical–biomechanical properties unique to cardiomyocytes and better stimulate and understand the influence of blood flow on the human vasculature. Such studies have helped increase our understanding of many cardiovascular diseases in general; as such, we present here a review of the current state of the field and potential for the future. |
topic |
lab-on-a-chip cardiovascular disease microfluidics cell culture |
url |
https://www.mdpi.com/2072-666X/11/10/898 |
work_keys_str_mv |
AT seanbeverung labonachipforcardiovascularphysiologyandpathology AT jingwenwu labonachipforcardiovascularphysiologyandpathology AT robertsteward labonachipforcardiovascularphysiologyandpathology |
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