Association of Single Nucleotide Polymorphism in Chromosome 11 with Autism Spectrum Disorder
Several genetic loci in chromosomes 11 and 15 have recently been associated with non-syndromic autism spectrum disorder (ASD) in populations from North America and Europe. The aim of the present study was to investigate whether such an association exists in a Latvian population. Ninety-five patients...
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doaj-a9f295ce3ec74e28b27db65e997f96c52021-09-05T14:01:13ZengSciendoProceedings of the Latvian Academy of Sciences. Section B, Natural Sciences1407-009X2014-07-0167645345610.2478/prolas-2013-0079prolas-2013-0079Association of Single Nucleotide Polymorphism in Chromosome 11 with Autism Spectrum DisorderBauze Daiga0Piekuse Linda1Kevere Laura2Kronberga Zane3Riževs Arnis4Vaivade Iveta5Vīksne Kristīne6Andrēziņa Raisa7Lāce Baiba8Children’s University Hospital, Child Psychiatry Clinic, Juglas iela 20, Rîga, LV–1079, LATVIARīga Stradiņš University, Dzirciema 16, Rīga, LV-1007, LATVIAChildren’s University Hospital, Child Psychiatry Clinic, Juglas iela 20, Rîga, LV–1079, LATVIAChildren’s University Hospital, Child Psychiatry Clinic, Juglas iela 20, Rîga, LV–1079, LATVIAChildren’s University Hospital, Child Psychiatry Clinic, Juglas iela 20, Rîga, LV–1079, LATVIALatvian Biomedical Research and Study Centre, Rātsupītes iela 1, Rīga, LV-1067, LATVIALatvian Biomedical Research and Study Centre, Rātsupītes iela 1, Rīga, LV-1067, LATVIAChildren’s University Hospital, Child Psychiatry Clinic, Juglas iela 20, Rîga, LV–1079, LATVIALatvian Biomedical Research and Study Centre, Rātsupītes iela 1, Rīga, LV-1067, LATVIASeveral genetic loci in chromosomes 11 and 15 have recently been associated with non-syndromic autism spectrum disorder (ASD) in populations from North America and Europe. The aim of the present study was to investigate whether such an association exists in a Latvian population. Ninety-five patients with ASD in the age range 3–20 years (mean age 8 years, SD 3.18) participated in the study. The control group consisted of 161 healthy, non-related individuals without ASD randomly selected from the Latvian Genome Database. Four single nucleotide polymorphisms (SNPs) — rs11212733, SNP rs1394119, rs2421826, rs1454985 — were genotyped by the TaqMan method. Allele frequency differences between ASD patients and control subjects were compared for each SNP using a standard chi-square test with Bonferroni correction. The level of statistical significance was set at 0.05 for nominal association. Only the genetic marker rs11212733, localised on the long arm of chromosome 11 in locus 22.3, was found to be strongly associated with the ASD patient group (χ2 6.982, Padjusted 0.033, odds ratio 1.625). Our data demonstrating a significant relationship between the SNP rs11212733 and the development of ASD in a Latvian population suggest that it is not a population-specific relationship. Thus, future studies focusing on the DDX10 gene and related genetic loci are needed.https://doi.org/10.2478/prolas-2013-0079autism spectrum disorder (asd)single nucleotide polymorphisms (snps)rs11212733ddx10 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bauze Daiga Piekuse Linda Kevere Laura Kronberga Zane Riževs Arnis Vaivade Iveta Vīksne Kristīne Andrēziņa Raisa Lāce Baiba |
spellingShingle |
Bauze Daiga Piekuse Linda Kevere Laura Kronberga Zane Riževs Arnis Vaivade Iveta Vīksne Kristīne Andrēziņa Raisa Lāce Baiba Association of Single Nucleotide Polymorphism in Chromosome 11 with Autism Spectrum Disorder Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences autism spectrum disorder (asd) single nucleotide polymorphisms (snps) rs11212733 ddx10 |
author_facet |
Bauze Daiga Piekuse Linda Kevere Laura Kronberga Zane Riževs Arnis Vaivade Iveta Vīksne Kristīne Andrēziņa Raisa Lāce Baiba |
author_sort |
Bauze Daiga |
title |
Association of Single Nucleotide Polymorphism in Chromosome 11 with Autism Spectrum Disorder |
title_short |
Association of Single Nucleotide Polymorphism in Chromosome 11 with Autism Spectrum Disorder |
title_full |
Association of Single Nucleotide Polymorphism in Chromosome 11 with Autism Spectrum Disorder |
title_fullStr |
Association of Single Nucleotide Polymorphism in Chromosome 11 with Autism Spectrum Disorder |
title_full_unstemmed |
Association of Single Nucleotide Polymorphism in Chromosome 11 with Autism Spectrum Disorder |
title_sort |
association of single nucleotide polymorphism in chromosome 11 with autism spectrum disorder |
publisher |
Sciendo |
series |
Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences |
issn |
1407-009X |
publishDate |
2014-07-01 |
description |
Several genetic loci in chromosomes 11 and 15 have recently been associated with non-syndromic autism spectrum disorder (ASD) in populations from North America and Europe. The aim of the present study was to investigate whether such an association exists in a Latvian population. Ninety-five patients with ASD in the age range 3–20 years (mean age 8 years, SD 3.18) participated in the study. The control group consisted of 161 healthy, non-related individuals without ASD randomly selected from the Latvian Genome Database. Four single nucleotide polymorphisms (SNPs) — rs11212733, SNP rs1394119, rs2421826, rs1454985 — were genotyped by the TaqMan method. Allele frequency differences between ASD patients and control subjects were compared for each SNP using a standard chi-square test with Bonferroni correction. The level of statistical significance was set at 0.05 for nominal association. Only the genetic marker rs11212733, localised on the long arm of chromosome 11 in locus 22.3, was found to be strongly associated with the ASD patient group (χ2 6.982, Padjusted 0.033, odds ratio 1.625). Our data demonstrating a significant relationship between the SNP rs11212733 and the development of ASD in a Latvian population suggest that it is not a population-specific relationship. Thus, future studies focusing on the DDX10 gene and related genetic loci are needed. |
topic |
autism spectrum disorder (asd) single nucleotide polymorphisms (snps) rs11212733 ddx10 |
url |
https://doi.org/10.2478/prolas-2013-0079 |
work_keys_str_mv |
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