Association of Single Nucleotide Polymorphism in Chromosome 11 with Autism Spectrum Disorder

Several genetic loci in chromosomes 11 and 15 have recently been associated with non-syndromic autism spectrum disorder (ASD) in populations from North America and Europe. The aim of the present study was to investigate whether such an association exists in a Latvian population. Ninety-five patients...

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Main Authors: Bauze Daiga, Piekuse Linda, Kevere Laura, Kronberga Zane, Riževs Arnis, Vaivade Iveta, Vīksne Kristīne, Andrēziņa Raisa, Lāce Baiba
Format: Article
Language:English
Published: Sciendo 2014-07-01
Series:Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences
Subjects:
Online Access:https://doi.org/10.2478/prolas-2013-0079
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spelling doaj-a9f295ce3ec74e28b27db65e997f96c52021-09-05T14:01:13ZengSciendoProceedings of the Latvian Academy of Sciences. Section B, Natural Sciences1407-009X2014-07-0167645345610.2478/prolas-2013-0079prolas-2013-0079Association of Single Nucleotide Polymorphism in Chromosome 11 with Autism Spectrum DisorderBauze Daiga0Piekuse Linda1Kevere Laura2Kronberga Zane3Riževs Arnis4Vaivade Iveta5Vīksne Kristīne6Andrēziņa Raisa7Lāce Baiba8Children’s University Hospital, Child Psychiatry Clinic, Juglas iela 20, Rîga, LV–1079, LATVIARīga Stradiņš University, Dzirciema 16, Rīga, LV-1007, LATVIAChildren’s University Hospital, Child Psychiatry Clinic, Juglas iela 20, Rîga, LV–1079, LATVIAChildren’s University Hospital, Child Psychiatry Clinic, Juglas iela 20, Rîga, LV–1079, LATVIAChildren’s University Hospital, Child Psychiatry Clinic, Juglas iela 20, Rîga, LV–1079, LATVIALatvian Biomedical Research and Study Centre, Rātsupītes iela 1, Rīga, LV-1067, LATVIALatvian Biomedical Research and Study Centre, Rātsupītes iela 1, Rīga, LV-1067, LATVIAChildren’s University Hospital, Child Psychiatry Clinic, Juglas iela 20, Rîga, LV–1079, LATVIALatvian Biomedical Research and Study Centre, Rātsupītes iela 1, Rīga, LV-1067, LATVIASeveral genetic loci in chromosomes 11 and 15 have recently been associated with non-syndromic autism spectrum disorder (ASD) in populations from North America and Europe. The aim of the present study was to investigate whether such an association exists in a Latvian population. Ninety-five patients with ASD in the age range 3–20 years (mean age 8 years, SD 3.18) participated in the study. The control group consisted of 161 healthy, non-related individuals without ASD randomly selected from the Latvian Genome Database. Four single nucleotide polymorphisms (SNPs) — rs11212733, SNP rs1394119, rs2421826, rs1454985 — were genotyped by the TaqMan method. Allele frequency differences between ASD patients and control subjects were compared for each SNP using a standard chi-square test with Bonferroni correction. The level of statistical significance was set at 0.05 for nominal association. Only the genetic marker rs11212733, localised on the long arm of chromosome 11 in locus 22.3, was found to be strongly associated with the ASD patient group (χ2 6.982, Padjusted 0.033, odds ratio 1.625). Our data demonstrating a significant relationship between the SNP rs11212733 and the development of ASD in a Latvian population suggest that it is not a population-specific relationship. Thus, future studies focusing on the DDX10 gene and related genetic loci are needed.https://doi.org/10.2478/prolas-2013-0079autism spectrum disorder (asd)single nucleotide polymorphisms (snps)rs11212733ddx10
collection DOAJ
language English
format Article
sources DOAJ
author Bauze Daiga
Piekuse Linda
Kevere Laura
Kronberga Zane
Riževs Arnis
Vaivade Iveta
Vīksne Kristīne
Andrēziņa Raisa
Lāce Baiba
spellingShingle Bauze Daiga
Piekuse Linda
Kevere Laura
Kronberga Zane
Riževs Arnis
Vaivade Iveta
Vīksne Kristīne
Andrēziņa Raisa
Lāce Baiba
Association of Single Nucleotide Polymorphism in Chromosome 11 with Autism Spectrum Disorder
Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences
autism spectrum disorder (asd)
single nucleotide polymorphisms (snps)
rs11212733
ddx10
author_facet Bauze Daiga
Piekuse Linda
Kevere Laura
Kronberga Zane
Riževs Arnis
Vaivade Iveta
Vīksne Kristīne
Andrēziņa Raisa
Lāce Baiba
author_sort Bauze Daiga
title Association of Single Nucleotide Polymorphism in Chromosome 11 with Autism Spectrum Disorder
title_short Association of Single Nucleotide Polymorphism in Chromosome 11 with Autism Spectrum Disorder
title_full Association of Single Nucleotide Polymorphism in Chromosome 11 with Autism Spectrum Disorder
title_fullStr Association of Single Nucleotide Polymorphism in Chromosome 11 with Autism Spectrum Disorder
title_full_unstemmed Association of Single Nucleotide Polymorphism in Chromosome 11 with Autism Spectrum Disorder
title_sort association of single nucleotide polymorphism in chromosome 11 with autism spectrum disorder
publisher Sciendo
series Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences
issn 1407-009X
publishDate 2014-07-01
description Several genetic loci in chromosomes 11 and 15 have recently been associated with non-syndromic autism spectrum disorder (ASD) in populations from North America and Europe. The aim of the present study was to investigate whether such an association exists in a Latvian population. Ninety-five patients with ASD in the age range 3–20 years (mean age 8 years, SD 3.18) participated in the study. The control group consisted of 161 healthy, non-related individuals without ASD randomly selected from the Latvian Genome Database. Four single nucleotide polymorphisms (SNPs) — rs11212733, SNP rs1394119, rs2421826, rs1454985 — were genotyped by the TaqMan method. Allele frequency differences between ASD patients and control subjects were compared for each SNP using a standard chi-square test with Bonferroni correction. The level of statistical significance was set at 0.05 for nominal association. Only the genetic marker rs11212733, localised on the long arm of chromosome 11 in locus 22.3, was found to be strongly associated with the ASD patient group (χ2 6.982, Padjusted 0.033, odds ratio 1.625). Our data demonstrating a significant relationship between the SNP rs11212733 and the development of ASD in a Latvian population suggest that it is not a population-specific relationship. Thus, future studies focusing on the DDX10 gene and related genetic loci are needed.
topic autism spectrum disorder (asd)
single nucleotide polymorphisms (snps)
rs11212733
ddx10
url https://doi.org/10.2478/prolas-2013-0079
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