CASE OF THE LATE DIAGNOSIS OF POEMS-SYNDROME
POEMS-syndrome (P — polyneuropathy, O — organomegaly, E — endocrinopathy, M — M-protein, S — skin) in 64-year old patient isdescribed in the article. The clinical picture was marked by such symptoms, as polyneuropathy, multiple myeloma, organomegaly (hepatosplenomegaly), endocrinopathy (diabetes), s...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | Russian |
Published: |
ABV-press
2014-07-01
|
Series: | Klinicist |
Subjects: | |
Online Access: | https://klinitsist.abvpress.ru/Klin/article/view/85 |
id |
doaj-a9f96045026c4e30ab8dd9ffe7cfc136 |
---|---|
record_format |
Article |
spelling |
doaj-a9f96045026c4e30ab8dd9ffe7cfc1362021-08-02T08:49:43ZrusABV-pressKlinicist1818-83382014-07-0154485210.17650/1818-8338-2011-4-48-52100CASE OF THE LATE DIAGNOSIS OF POEMS-SYNDROMEP. N. Barlamov0M. E. Golubeva1E. R. Vasiliev2S. V. Meres3V. V. Shchekotov4Perm City Hematological Center Perm State Medical AcademyPerm City Hematological Center Perm State Medical AcademyPerm City Hematological Center Perm State Medical AcademyPerm City Hematological Center Perm State Medical AcademyPerm City Hematological Center Perm State Medical AcademyPOEMS-syndrome (P — polyneuropathy, O — organomegaly, E — endocrinopathy, M — M-protein, S — skin) in 64-year old patient isdescribed in the article. The clinical picture was marked by such symptoms, as polyneuropathy, multiple myeloma, organomegaly (hepatosplenomegaly), endocrinopathy (diabetes), skin changes (redness and induration of the dermis in the neck), fever, hypoproteinemia, edema, weight loss, thrombocytosis. Bone-destructive syndrome was absent. In myelogram 18 % of the cells with signs of some plasmatic anaplasia were found. In blood, low level of paraprotein secretion Aλ, increased β2-microglobulin was fixed. A course of therapy with prednisolone and alkeranom was accompanied by slight positive effect. However, a second course was interrupted in the third day due to worsening of concomitant cardiac disease (ischemic heart disease in combination with hypertension). Last episode of recurrent of pulmonary edema occurred fatal. Autopsy study was not conducted. This observation illustrates the need for more rigorous examination (myelogram, immunochemical study of blood and urine) in the presence of clinical signs of POEMS-syndrome for the timely diagnosis of the underlying disease and its treatment.https://klinitsist.abvpress.ru/Klin/article/view/85poems-syndromepolyneuropathymonoclonal gammopathyorganomegalyhepatosplenomegalyparaproteinendocrinopathydiabetesmultiple myelomaplasmacytomaalkeranprednisone |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
P. N. Barlamov M. E. Golubeva E. R. Vasiliev S. V. Meres V. V. Shchekotov |
spellingShingle |
P. N. Barlamov M. E. Golubeva E. R. Vasiliev S. V. Meres V. V. Shchekotov CASE OF THE LATE DIAGNOSIS OF POEMS-SYNDROME Klinicist poems-syndrome polyneuropathy monoclonal gammopathy organomegaly hepatosplenomegaly paraprotein endocrinopathy diabetes multiple myeloma plasmacytoma alkeran prednisone |
author_facet |
P. N. Barlamov M. E. Golubeva E. R. Vasiliev S. V. Meres V. V. Shchekotov |
author_sort |
P. N. Barlamov |
title |
CASE OF THE LATE DIAGNOSIS OF POEMS-SYNDROME |
title_short |
CASE OF THE LATE DIAGNOSIS OF POEMS-SYNDROME |
title_full |
CASE OF THE LATE DIAGNOSIS OF POEMS-SYNDROME |
title_fullStr |
CASE OF THE LATE DIAGNOSIS OF POEMS-SYNDROME |
title_full_unstemmed |
CASE OF THE LATE DIAGNOSIS OF POEMS-SYNDROME |
title_sort |
case of the late diagnosis of poems-syndrome |
publisher |
ABV-press |
series |
Klinicist |
issn |
1818-8338 |
publishDate |
2014-07-01 |
description |
POEMS-syndrome (P — polyneuropathy, O — organomegaly, E — endocrinopathy, M — M-protein, S — skin) in 64-year old patient isdescribed in the article. The clinical picture was marked by such symptoms, as polyneuropathy, multiple myeloma, organomegaly (hepatosplenomegaly), endocrinopathy (diabetes), skin changes (redness and induration of the dermis in the neck), fever, hypoproteinemia, edema, weight loss, thrombocytosis. Bone-destructive syndrome was absent. In myelogram 18 % of the cells with signs of some plasmatic anaplasia were found. In blood, low level of paraprotein secretion Aλ, increased β2-microglobulin was fixed. A course of therapy with prednisolone and alkeranom was accompanied by slight positive effect. However, a second course was interrupted in the third day due to worsening of concomitant cardiac disease (ischemic heart disease in combination with hypertension). Last episode of recurrent of pulmonary edema occurred fatal. Autopsy study was not conducted. This observation illustrates the need for more rigorous examination (myelogram, immunochemical study of blood and urine) in the presence of clinical signs of POEMS-syndrome for the timely diagnosis of the underlying disease and its treatment. |
topic |
poems-syndrome polyneuropathy monoclonal gammopathy organomegaly hepatosplenomegaly paraprotein endocrinopathy diabetes multiple myeloma plasmacytoma alkeran prednisone |
url |
https://klinitsist.abvpress.ru/Klin/article/view/85 |
work_keys_str_mv |
AT pnbarlamov caseofthelatediagnosisofpoemssyndrome AT megolubeva caseofthelatediagnosisofpoemssyndrome AT ervasiliev caseofthelatediagnosisofpoemssyndrome AT svmeres caseofthelatediagnosisofpoemssyndrome AT vvshchekotov caseofthelatediagnosisofpoemssyndrome |
_version_ |
1721237106053873664 |