Targeting HIF-1α Regulatory Pathways as a Strategy to Hamper Tumor-Microenvironment Interactions in CLL

Targeting HIF-1α Regulatory Pathways as a Strategy to Hamper Tumor-Microenvironment Interactions in CLL

The hypoxia-inducible factor 1 (HIF-1) and the CXCL12/CXCR4 axis regulate the interaction of chronic lymphocytic leukemia cells and the tumor microenvironment. However, the interconnections occurring between HIF-1 and the CXCL12/CXCR4 axis are not fully elucidated. Here, we demonstrate that the CXCL...

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Bibliographic Details
Main Authors: Candida Vitale, Valentina Griggio, Chiara Riganti, Maria Todaro, Joanna Kopecka, Rebecca Jones, Chiara Salvetti, Elia Boccellato, Francesca Perutelli, Claudia Voena, Laura Godio, Mario Boccadoro, Marta Coscia
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
chronic lymphocytic leukemia
tumor microenvironment
hypoxia inducible factor-1α
CXCL12/CXCR4 axis
drug resistance
Online Access:https://www.mdpi.com/2072-6694/13/12/2883

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