Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies
Alzheimer’s disease (AD) is the leading cause of dementia worldwide. It involves progressive impairment of cognitive function. A growing number of neuroprotective compounds have been identified with potential anti-AD properties through in vitro and in vivo models of AD. Quercetin, a natura...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-01-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/2/493 |
id |
doaj-a9fc4645a5734cbb8bd1e4f54a2a3397 |
---|---|
record_format |
Article |
spelling |
doaj-a9fc4645a5734cbb8bd1e4f54a2a33972020-11-25T01:27:39ZengMDPI AGInternational Journal of Molecular Sciences1422-00672020-01-0121249310.3390/ijms21020493ijms21020493Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical StudiesXiao-Wen Zhang0Jia-Yue Chen1Defang Ouyang2Jia-Hong Lu3State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, MacaoState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, MacaoState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, MacaoState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, MacaoAlzheimer’s disease (AD) is the leading cause of dementia worldwide. It involves progressive impairment of cognitive function. A growing number of neuroprotective compounds have been identified with potential anti-AD properties through in vitro and in vivo models of AD. Quercetin, a natural flavonoid contained in a wide range of plant species, is repeatedly reported to exert neuroprotective effects in experimental animal AD models. However, a systematic analysis of methodological rigor and the comparison between different studies is still lacking. A systematic review uses a methodical approach to minimize the bias in each independent study, providing a less biased, comprehensive understanding of research findings and an objective judgement of the strength of evidence and the reliability of conclusions. In this review, we identified 14 studies describing the therapeutic efficacy of quercetin on animal AD models by electronic and manual retrieval. Some of the results of the studies included were meta-analyzed by forest plot, and the methodological quality of each preclinical trial was assessed with SYRCLE’s risk of bias tool. Our results demonstrated the consistent neuroprotective effects of quercetin on different AD models, and the pharmacological mechanisms of quercetin on AD models are summarized. This information eliminated the bias of each individual study, providing guidance for future tests and supporting evidence for further implementation of quercetin into clinical trials. However, the limitations of some studies, such as the absence of sample size calculations and low method quality, should also be noted.https://www.mdpi.com/1422-0067/21/2/493alzheimer’s diseasequercetinneuroprotective effectsanimal ad models |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiao-Wen Zhang Jia-Yue Chen Defang Ouyang Jia-Hong Lu |
spellingShingle |
Xiao-Wen Zhang Jia-Yue Chen Defang Ouyang Jia-Hong Lu Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies International Journal of Molecular Sciences alzheimer’s disease quercetin neuroprotective effects animal ad models |
author_facet |
Xiao-Wen Zhang Jia-Yue Chen Defang Ouyang Jia-Hong Lu |
author_sort |
Xiao-Wen Zhang |
title |
Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies |
title_short |
Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies |
title_full |
Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies |
title_fullStr |
Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies |
title_full_unstemmed |
Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies |
title_sort |
quercetin in animal models of alzheimer’s disease: a systematic review of preclinical studies |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2020-01-01 |
description |
Alzheimer’s disease (AD) is the leading cause of dementia worldwide. It involves progressive impairment of cognitive function. A growing number of neuroprotective compounds have been identified with potential anti-AD properties through in vitro and in vivo models of AD. Quercetin, a natural flavonoid contained in a wide range of plant species, is repeatedly reported to exert neuroprotective effects in experimental animal AD models. However, a systematic analysis of methodological rigor and the comparison between different studies is still lacking. A systematic review uses a methodical approach to minimize the bias in each independent study, providing a less biased, comprehensive understanding of research findings and an objective judgement of the strength of evidence and the reliability of conclusions. In this review, we identified 14 studies describing the therapeutic efficacy of quercetin on animal AD models by electronic and manual retrieval. Some of the results of the studies included were meta-analyzed by forest plot, and the methodological quality of each preclinical trial was assessed with SYRCLE’s risk of bias tool. Our results demonstrated the consistent neuroprotective effects of quercetin on different AD models, and the pharmacological mechanisms of quercetin on AD models are summarized. This information eliminated the bias of each individual study, providing guidance for future tests and supporting evidence for further implementation of quercetin into clinical trials. However, the limitations of some studies, such as the absence of sample size calculations and low method quality, should also be noted. |
topic |
alzheimer’s disease quercetin neuroprotective effects animal ad models |
url |
https://www.mdpi.com/1422-0067/21/2/493 |
work_keys_str_mv |
AT xiaowenzhang quercetininanimalmodelsofalzheimersdiseaseasystematicreviewofpreclinicalstudies AT jiayuechen quercetininanimalmodelsofalzheimersdiseaseasystematicreviewofpreclinicalstudies AT defangouyang quercetininanimalmodelsofalzheimersdiseaseasystematicreviewofpreclinicalstudies AT jiahonglu quercetininanimalmodelsofalzheimersdiseaseasystematicreviewofpreclinicalstudies |
_version_ |
1725103905083228160 |