Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

Circulating memory cells include central memory T cells retaining the ability to enter the lymph nodes whereas tissue resident memory cells are confined to the parenchymal tissues. Here the authors explore the interplay between the two T-cell types and show that both cooperate in anti-tumour immunit...

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Main Authors: Michel Enamorado, Salvador Iborra, Elena Priego, Francisco J. Cueto, Juan A. Quintana, Sarai Martínez-Cano, Ernesto Mejías-Pérez, Mariano Esteban, Ignacio Melero, Andrés Hidalgo, David Sancho
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms16073
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spelling doaj-aa0049fe97b2432095bd04330e3dc3662021-05-11T07:30:07ZengNature Publishing GroupNature Communications2041-17232017-07-018111110.1038/ncomms16073Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cellsMichel Enamorado0Salvador Iborra1Elena Priego2Francisco J. Cueto3Juan A. Quintana4Sarai Martínez-Cano5Ernesto Mejías-Pérez6Mariano Esteban7Ignacio Melero8Andrés Hidalgo9David Sancho10Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Department of Molecular and Cellular Biology, Centro Nacional de BiotecnologíaDepartment of Molecular and Cellular Biology, Centro Nacional de BiotecnologíaDivision of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Circulating memory cells include central memory T cells retaining the ability to enter the lymph nodes whereas tissue resident memory cells are confined to the parenchymal tissues. Here the authors explore the interplay between the two T-cell types and show that both cooperate in anti-tumour immunity.https://doi.org/10.1038/ncomms16073
collection DOAJ
language English
format Article
sources DOAJ
author Michel Enamorado
Salvador Iborra
Elena Priego
Francisco J. Cueto
Juan A. Quintana
Sarai Martínez-Cano
Ernesto Mejías-Pérez
Mariano Esteban
Ignacio Melero
Andrés Hidalgo
David Sancho
spellingShingle Michel Enamorado
Salvador Iborra
Elena Priego
Francisco J. Cueto
Juan A. Quintana
Sarai Martínez-Cano
Ernesto Mejías-Pérez
Mariano Esteban
Ignacio Melero
Andrés Hidalgo
David Sancho
Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells
Nature Communications
author_facet Michel Enamorado
Salvador Iborra
Elena Priego
Francisco J. Cueto
Juan A. Quintana
Sarai Martínez-Cano
Ernesto Mejías-Pérez
Mariano Esteban
Ignacio Melero
Andrés Hidalgo
David Sancho
author_sort Michel Enamorado
title Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells
title_short Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells
title_full Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells
title_fullStr Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells
title_full_unstemmed Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells
title_sort enhanced anti-tumour immunity requires the interplay between resident and circulating memory cd8+ t cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-07-01
description Circulating memory cells include central memory T cells retaining the ability to enter the lymph nodes whereas tissue resident memory cells are confined to the parenchymal tissues. Here the authors explore the interplay between the two T-cell types and show that both cooperate in anti-tumour immunity.
url https://doi.org/10.1038/ncomms16073
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