Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease
The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating cell growth, proliferation, and life span. mTOR signaling is a central regulator of autophagy by modulating multiple aspects of the autophagy process, such as initiation, process, and termination through c...
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doaj-aa0073fd82c3464e9dc7eb5f1f5bd6fb2020-11-25T02:23:50ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-02-0120372810.3390/ijms20030728ijms20030728Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s DiseaseZhou Zhu0Chuanbin Yang1Ashok Iyaswamy2Senthilkumar Krishnamoorthi3Sravan Gopalkrishnashetty Sreenivasmurthy4Jia Liu5Ziying Wang6Benjamin Chun-Kit Tong7Juxian Song8Jiahong Lu9King-Ho Cheung10Min Li11Mr. and Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR 999077, ChinaMr. and Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR 999077, ChinaMr. and Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR 999077, ChinaMr. and Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR 999077, ChinaMr. and Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR 999077, ChinaMr. and Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR 999077, ChinaMr. and Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR 999077, ChinaMr. and Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR 999077, ChinaMedical College of Acupuncture-Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR 999078, ChinaMr. and Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR 999077, ChinaMr. and Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR 999077, ChinaThe mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating cell growth, proliferation, and life span. mTOR signaling is a central regulator of autophagy by modulating multiple aspects of the autophagy process, such as initiation, process, and termination through controlling the activity of the unc51-like kinase 1 (ULK1) complex and vacuolar protein sorting 34 (VPS34) complex, and the intracellular distribution of TFEB/TFE3 and proto-lysosome tubule reformation. Parkinson’s disease (PD) is a serious, common neurodegenerative disease characterized by dopaminergic neuron loss in the substantia nigra pars compacta (SNpc) and the accumulation of Lewy bodies. An increasing amount of evidence indicates that mTOR and autophagy are critical for the pathogenesis of PD. In this review, we will summarize recent advances regarding the roles of mTOR and autophagy in PD pathogenesis and treatment. Further characterizing the dysregulation of mTOR pathway and the clinical translation of mTOR modulators in PD may offer exciting new avenues for future drug development.https://www.mdpi.com/1422-0067/20/3/728mTORautophagyParkinson’s disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhou Zhu Chuanbin Yang Ashok Iyaswamy Senthilkumar Krishnamoorthi Sravan Gopalkrishnashetty Sreenivasmurthy Jia Liu Ziying Wang Benjamin Chun-Kit Tong Juxian Song Jiahong Lu King-Ho Cheung Min Li |
spellingShingle |
Zhou Zhu Chuanbin Yang Ashok Iyaswamy Senthilkumar Krishnamoorthi Sravan Gopalkrishnashetty Sreenivasmurthy Jia Liu Ziying Wang Benjamin Chun-Kit Tong Juxian Song Jiahong Lu King-Ho Cheung Min Li Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease International Journal of Molecular Sciences mTOR autophagy Parkinson’s disease |
author_facet |
Zhou Zhu Chuanbin Yang Ashok Iyaswamy Senthilkumar Krishnamoorthi Sravan Gopalkrishnashetty Sreenivasmurthy Jia Liu Ziying Wang Benjamin Chun-Kit Tong Juxian Song Jiahong Lu King-Ho Cheung Min Li |
author_sort |
Zhou Zhu |
title |
Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease |
title_short |
Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease |
title_full |
Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease |
title_fullStr |
Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease |
title_full_unstemmed |
Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease |
title_sort |
balancing mtor signaling and autophagy in the treatment of parkinson’s disease |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-02-01 |
description |
The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating cell growth, proliferation, and life span. mTOR signaling is a central regulator of autophagy by modulating multiple aspects of the autophagy process, such as initiation, process, and termination through controlling the activity of the unc51-like kinase 1 (ULK1) complex and vacuolar protein sorting 34 (VPS34) complex, and the intracellular distribution of TFEB/TFE3 and proto-lysosome tubule reformation. Parkinson’s disease (PD) is a serious, common neurodegenerative disease characterized by dopaminergic neuron loss in the substantia nigra pars compacta (SNpc) and the accumulation of Lewy bodies. An increasing amount of evidence indicates that mTOR and autophagy are critical for the pathogenesis of PD. In this review, we will summarize recent advances regarding the roles of mTOR and autophagy in PD pathogenesis and treatment. Further characterizing the dysregulation of mTOR pathway and the clinical translation of mTOR modulators in PD may offer exciting new avenues for future drug development. |
topic |
mTOR autophagy Parkinson’s disease |
url |
https://www.mdpi.com/1422-0067/20/3/728 |
work_keys_str_mv |
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