Effect of adjuvant ginkgo-damole therapy on the plaque stability, apoptosis and coagulation indicators in patients with unstable angina

• Main Author: Ying Jiang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-07-01
• Series: Journal of Hainan Medical University
• Subjects: Unstable angina; Ginkgo-damole; Plaque stability; Apoptosis; Coagulation function
• Online Access: http://www.hnykdxxb.com/PDF/201713/9.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study the effect of adjuvant ginkgo-damole therapy on the plaque stability, apoptosis and coagulation indicators in patients with unstable angina. Methods: A total of 80 patients with unstable angina who received inpatient treatment in our hospital between July 2014 and July 2016 were collected and divided into control group (conventional therapy) and observation group (conventional therapy＋ginkgo-damole) according to the random number table, 40 cases in each group. The plaque stability, apoptosis and coagulation indicator contents were compared between two groups of patients before and after treatment. Results: Before treatment, differences in serum levels of plaque stability, apoptosis and coagulation indicators were not statistically significant between two groups of patients; after treatment, serum plaque stability indicators PTX3, Lp-PLA2, sCD40 and sCD40L contents in observation group were lower than those in control group; pro-apoptosis indexes sFas and Bax contents were lower than those in control group, and anti-apoptosis index Bcl-2 content was higher than that in control group; coagulation indicators Fg and D-D contents were lower than those in control group while t-PA content was higher than that in control group. Conclusion: Adjuvant ginkgodamole therapy helps to improve the plaque stability, inhibit myocardial apoptosis and also reduce the hypercoagulable state in patients with unstable angina.