Safety of treatment regimens in multiple drug resistant tuberculosis patients compiled as per the new WHO recommendations as of 2019
The objective: safety assessment of chemotherapy regimens compiled in accordance with the recommendations of World Health Organization (WHO), 2019, in patients with multiple drug resistant tuberculosis (MDR) in clinical practice settings.Subjects: Frequency, patterns, severity and risk factors of ad...
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2020-02-01
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doaj-aa12cd277c6d40c095fe9452a38e9ac32021-07-28T20:57:48ZrusNEW TERRA Publishing HouseTuberkulez i Bolezni Lëgkih2075-12302542-15062020-02-0198151510.21292/2075-1230-2020-98-1-5-151381Safety of treatment regimens in multiple drug resistant tuberculosis patients compiled as per the new WHO recommendations as of 2019D. A. Ivanova0S. E. Borisov1O. V. Rodina2A. V. Filippov3T. N. Ivanushkina4N. V. Litvinova5Moscow Municipal Scientific Practical Center of Tuberculosis ControlMoscow Municipal Scientific Practical Center of Tuberculosis ControlMoscow Municipal Scientific Practical Center of Tuberculosis ControlMoscow Municipal Scientific Practical Center of Tuberculosis ControlMoscow Municipal Scientific Practical Center of Tuberculosis ControlMoscow Municipal Scientific Practical Center of Tuberculosis ControlThe objective: safety assessment of chemotherapy regimens compiled in accordance with the recommendations of World Health Organization (WHO), 2019, in patients with multiple drug resistant tuberculosis (MDR) in clinical practice settings.Subjects: Frequency, patterns, severity and risk factors of adverse events (AE) of chemotherapy regimens compiled in accordance with the WHO recommendations as of 2019 were analyzed in 122 patients with MDR and XDR respiratory tuberculosis within programmatic use of new anti-tuberculosis drugs.Results. The frequency of AE made 64.8% (95% CI 55.9-72.7%), gastrointestinal, cardiovascular and allergic events prevailed, the comorbidity was the risk factor of AE development (OR 6.44; 95% CI 1.91-21.76). AEs of with severity degrees 3-4 were observed in 24.6% (95% CI 17.8-33.0%), neurotoxic, ototoxic and hepatotoxic reactions prevailed; risk factors included female sex (OR 3.15, 95% CI 1.32-7.53) and complications of chemotherapy in the past (OR 3.50%, 95% CI 1.49-8.70). At least one anti-tuberculosis drug was canceled due to AE in 26.2% (95% CI 19.2-34.7%), and any of Group A drugs was canceled during the first 6 months of chemotherapy in 13.9% (95% CI 8.8-21.3%) of patients.https://www.tibl-journal.com/jour/article/view/1381tuberculosismultiple drug resistance of tuberculosis mycobacteriaadverse reactionsrisk factors |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
D. A. Ivanova S. E. Borisov O. V. Rodina A. V. Filippov T. N. Ivanushkina N. V. Litvinova |
spellingShingle |
D. A. Ivanova S. E. Borisov O. V. Rodina A. V. Filippov T. N. Ivanushkina N. V. Litvinova Safety of treatment regimens in multiple drug resistant tuberculosis patients compiled as per the new WHO recommendations as of 2019 Tuberkulez i Bolezni Lëgkih tuberculosis multiple drug resistance of tuberculosis mycobacteria adverse reactions risk factors |
author_facet |
D. A. Ivanova S. E. Borisov O. V. Rodina A. V. Filippov T. N. Ivanushkina N. V. Litvinova |
author_sort |
D. A. Ivanova |
title |
Safety of treatment regimens in multiple drug resistant tuberculosis patients compiled as per the new WHO recommendations as of 2019 |
title_short |
Safety of treatment regimens in multiple drug resistant tuberculosis patients compiled as per the new WHO recommendations as of 2019 |
title_full |
Safety of treatment regimens in multiple drug resistant tuberculosis patients compiled as per the new WHO recommendations as of 2019 |
title_fullStr |
Safety of treatment regimens in multiple drug resistant tuberculosis patients compiled as per the new WHO recommendations as of 2019 |
title_full_unstemmed |
Safety of treatment regimens in multiple drug resistant tuberculosis patients compiled as per the new WHO recommendations as of 2019 |
title_sort |
safety of treatment regimens in multiple drug resistant tuberculosis patients compiled as per the new who recommendations as of 2019 |
publisher |
NEW TERRA Publishing House |
series |
Tuberkulez i Bolezni Lëgkih |
issn |
2075-1230 2542-1506 |
publishDate |
2020-02-01 |
description |
The objective: safety assessment of chemotherapy regimens compiled in accordance with the recommendations of World Health Organization (WHO), 2019, in patients with multiple drug resistant tuberculosis (MDR) in clinical practice settings.Subjects: Frequency, patterns, severity and risk factors of adverse events (AE) of chemotherapy regimens compiled in accordance with the WHO recommendations as of 2019 were analyzed in 122 patients with MDR and XDR respiratory tuberculosis within programmatic use of new anti-tuberculosis drugs.Results. The frequency of AE made 64.8% (95% CI 55.9-72.7%), gastrointestinal, cardiovascular and allergic events prevailed, the comorbidity was the risk factor of AE development (OR 6.44; 95% CI 1.91-21.76). AEs of with severity degrees 3-4 were observed in 24.6% (95% CI 17.8-33.0%), neurotoxic, ototoxic and hepatotoxic reactions prevailed; risk factors included female sex (OR 3.15, 95% CI 1.32-7.53) and complications of chemotherapy in the past (OR 3.50%, 95% CI 1.49-8.70). At least one anti-tuberculosis drug was canceled due to AE in 26.2% (95% CI 19.2-34.7%), and any of Group A drugs was canceled during the first 6 months of chemotherapy in 13.9% (95% CI 8.8-21.3%) of patients. |
topic |
tuberculosis multiple drug resistance of tuberculosis mycobacteria adverse reactions risk factors |
url |
https://www.tibl-journal.com/jour/article/view/1381 |
work_keys_str_mv |
AT daivanova safetyoftreatmentregimensinmultipledrugresistanttuberculosispatientscompiledasperthenewwhorecommendationsasof2019 AT seborisov safetyoftreatmentregimensinmultipledrugresistanttuberculosispatientscompiledasperthenewwhorecommendationsasof2019 AT ovrodina safetyoftreatmentregimensinmultipledrugresistanttuberculosispatientscompiledasperthenewwhorecommendationsasof2019 AT avfilippov safetyoftreatmentregimensinmultipledrugresistanttuberculosispatientscompiledasperthenewwhorecommendationsasof2019 AT tnivanushkina safetyoftreatmentregimensinmultipledrugresistanttuberculosispatientscompiledasperthenewwhorecommendationsasof2019 AT nvlitvinova safetyoftreatmentregimensinmultipledrugresistanttuberculosispatientscompiledasperthenewwhorecommendationsasof2019 |
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1721263959166681088 |