NOX2 activation contributes to cobalt nanoparticles-induced inflammatory responses and Tau phosphorylation in mice and microglia

NOX2 activation contributes to cobalt nanoparticles-induced inflammatory responses and Tau phosphorylation in mice and microglia

Despite the wide application of cobalt nanoparticles (CoNPs), its neurotoxicity and the underlying mechanisms are not fully understood. In this study, CoNPs-induced toxic effect was examined in both C57BL/6J mice and microglial BV2 cells. CoNPs-induced brain weight loss and the reduction of Nissl bo...

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Bibliographic Details
Main Authors: Jing Li, Junxiang Wang, Yuan-Liang Wang, Zhousong Luo, Chunyan Zheng, Guangxia Yu, Siying Wu, Fuli Zheng, Huangyuan Li
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Ecotoxicology and Environmental Safety
Subjects:
CoNPs
NOX2
Tau phosphorylation
Inflammation
Microglia
Online Access:http://www.sciencedirect.com/science/article/pii/S014765132100837X

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