STRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1
BRCA1, a multi-domain protein, is mutated in a large percentage of hereditary breast and ovarian cancers. BRCA1 is most often mutated in three domains or regions: the N-terminal RING domain, exons 11–13, and the BRCT domain. The BRCA1 RING domain is responsible for the E3 ubiquitin ligase activity o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2012-04-01
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| Series: | Computational and Structural Biotechnology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037014601070 |
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by Serena L. Clark, Ana M. Rodriguez, Russell R. Snyder, Gary D.V. Hankins, Darren Boehning
Published 2012-04-01
Get full textPublished 2012-04-01
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