Research progress of SIRT1 as a target for the treatment of age-related retinal disease
Silent information regulator protein 1(SIRT1)is one of the sirtuins and belongs to histone deacetyase. Its activity depends on nicotinamide adenine dinucleotide(NAD<sup>+</sup>)and is regulated by NAD<sup>+</sup>. Experimental and clinical studies have shown the neuro-protect...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2015-02-01
|
| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2015/2/201502012.pdf |
| id |
doaj-aa3b37d81e2249aa9dc8a0bafa1935dc |
|---|---|
| record_format |
Article |
| spelling |
doaj-aa3b37d81e2249aa9dc8a0bafa1935dc2020-11-24T22:16:21ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232015-02-0115223323710.3980/j.issn.1672-5123.2015.2.12Research progress of SIRT1 as a target for the treatment of age-related retinal diseaseYan Zhang0Bo-Yu Lu1Hui-Min Zhang2Shi-Hui Wei3Deparment of Ophthalmology, General Hospital of Chinese PLA, Beijing 100039, China; Department of Ophthalmology, Beijing Military General Hospital of Chinese PLA, Beijing 100700, ChinaDepartment of Ophthalmology, Beijing Military General Hospital of Chinese PLA, Beijing 100700, ChinaDepartment of Ophthalmology, Beijing Military General Hospital of Chinese PLA, Beijing 100700, ChinaDeparment of Ophthalmology, General Hospital of Chinese PLA, Beijing 100039, ChinaSilent information regulator protein 1(SIRT1)is one of the sirtuins and belongs to histone deacetyase. Its activity depends on nicotinamide adenine dinucleotide(NAD<sup>+</sup>)and is regulated by NAD<sup>+</sup>. Experimental and clinical studies have shown the neuro-protective effect of SIRT1 in the pathogenesis of age-related eye diseases. In this review, the relationship between SIRT1 activator and apoptosis in the retinal cells were discussed. The review also points to SIRT1 as a potential therapeutic target for the clinical management of age-related retinal disease.http://ies.ijo.cn/cn_publish/2015/2/201502012.pdfsilent information regulator protein 1neuro-protective effectresearch progressionage-related retinal disease |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yan Zhang Bo-Yu Lu Hui-Min Zhang Shi-Hui Wei |
| spellingShingle |
Yan Zhang Bo-Yu Lu Hui-Min Zhang Shi-Hui Wei Research progress of SIRT1 as a target for the treatment of age-related retinal disease Guoji Yanke Zazhi silent information regulator protein 1 neuro-protective effect research progression age-related retinal disease |
| author_facet |
Yan Zhang Bo-Yu Lu Hui-Min Zhang Shi-Hui Wei |
| author_sort |
Yan Zhang |
| title |
Research progress of SIRT1 as a target for the treatment of age-related retinal disease |
| title_short |
Research progress of SIRT1 as a target for the treatment of age-related retinal disease |
| title_full |
Research progress of SIRT1 as a target for the treatment of age-related retinal disease |
| title_fullStr |
Research progress of SIRT1 as a target for the treatment of age-related retinal disease |
| title_full_unstemmed |
Research progress of SIRT1 as a target for the treatment of age-related retinal disease |
| title_sort |
research progress of sirt1 as a target for the treatment of age-related retinal disease |
| publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
| series |
Guoji Yanke Zazhi |
| issn |
1672-5123 1672-5123 |
| publishDate |
2015-02-01 |
| description |
Silent information regulator protein 1(SIRT1)is one of the sirtuins and belongs to histone deacetyase. Its activity depends on nicotinamide adenine dinucleotide(NAD<sup>+</sup>)and is regulated by NAD<sup>+</sup>. Experimental and clinical studies have shown the neuro-protective effect of SIRT1 in the pathogenesis of age-related eye diseases. In this review, the relationship between SIRT1 activator and apoptosis in the retinal cells were discussed. The review also points to SIRT1 as a potential therapeutic target for the clinical management of age-related retinal disease. |
| topic |
silent information regulator protein 1 neuro-protective effect research progression age-related retinal disease |
| url |
http://ies.ijo.cn/cn_publish/2015/2/201502012.pdf |
| work_keys_str_mv |
AT yanzhang researchprogressofsirt1asatargetforthetreatmentofagerelatedretinaldisease AT boyulu researchprogressofsirt1asatargetforthetreatmentofagerelatedretinaldisease AT huiminzhang researchprogressofsirt1asatargetforthetreatmentofagerelatedretinaldisease AT shihuiwei researchprogressofsirt1asatargetforthetreatmentofagerelatedretinaldisease |
| _version_ |
1725790548086751232 |