The Latin American Spanish version of the Face-Name Associative Memory Exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer’s disease
Abstract Background To determine whether performance on the Latin American Spanish version of the Face-Name Associative Memory Exam (LAS-FNAME) can differentiate between cognitively intact carriers of an autosomal dominant Alzheimer’s disease mutation (E280A) in Presenilin-1, who are genetically det...
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doaj-aa400d994d1a43edb52357ab5fbd7fb42020-11-25T02:49:29ZengBMCAlzheimer’s Research & Therapy1758-91932020-09-0112111110.1186/s13195-020-00671-wThe Latin American Spanish version of the Face-Name Associative Memory Exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer’s diseaseClara Vila-Castelar0Nathalia Muñoz1Kathryn V. Papp2Rebecca E. Amariglio3Ana Baena4Edmarie Guzmán-Vélez5Yamile Bocanegra6Justin S. Sanchez7Eric M. Reiman8Keith A. Johnson9Reisa A. Sperling10Francisco Lopera11Dorene M. Rentz12Yakeel T. Quiroz13Department of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Neurology, Brigham and Women’s Hospital, Harvard Medical SchoolDepartment of Neurology, Brigham and Women’s Hospital, Harvard Medical SchoolGrupo de Neurociencias de Antioquia, Universidad de AntioquiaDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolGrupo de Neurociencias de Antioquia, Universidad de AntioquiaDepartment of Neurology, Massachusetts General Hospital, Harvard Medical SchoolBanner Alzheimer’s InstituteDepartment of Neurology, Brigham and Women’s Hospital, Harvard Medical SchoolDepartment of Neurology, Brigham and Women’s Hospital, Harvard Medical SchoolGrupo de Neurociencias de Antioquia, Universidad de AntioquiaDepartment of Neurology, Brigham and Women’s Hospital, Harvard Medical SchoolDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolAbstract Background To determine whether performance on the Latin American Spanish version of the Face-Name Associative Memory Exam (LAS-FNAME) can differentiate between cognitively intact carriers of an autosomal dominant Alzheimer’s disease mutation (E280A) in Presenilin-1, who are genetically determined to develop early-onset dementia, from matched non-carriers. We also sought to examine whether LAS-FNAME performance is associated with amyloid-β and regional tau burden in mutation carriers. Methods A total of 35 cognitively intact mutation carriers (age range 26–41), 19 symptomatic carriers, and 48 matched non-carriers (age range 27–44) completed a neuropsychological assessment including the LAS-FNAME. A subset of participants (31 carriers [12 symptomatic] and 35 non-carriers) traveled from Colombia to Boston to undergo positron emission tomography (PET) using Pittsburgh compound B to measure mean cortical amyloid-β and flortaucipir for regional tau. ANOVA analyses and Spearman correlations were used to examine group differences and relationships among LAS-FNAME performance and amyloid-β and tau accumulation. Results Compared to non-carriers, cognitively intact mutation carriers had lower scores on the LAS-FNAME Total Scores (p = .040). Across all carriers (including symptomatic carriers), higher levels of amyloid-β (r = − .436, p = .018) and regional tau in the entorhinal (r = − .394, p = .031) and inferior temporal cortex (r = − .563, p = .001) were associated with lower LAS-FNAME Total Scores. Conclusions Performance on the LAS-FNAME differentiated between cognitively intact mutation carriers from non-carriers and was associated with greater amyloid and tau burden when examining all carriers. Findings suggest that the LAS-FNAME is sensitive to early clinical and pathological changes and can potentially help track disease progression in Spanish-speaking individuals.http://link.springer.com/article/10.1186/s13195-020-00671-wAlzheimer’s diseaseAutosomal dominant Alzheimer’s diseaseNeuropsychologyAssociative memoryImagingPET |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Clara Vila-Castelar Nathalia Muñoz Kathryn V. Papp Rebecca E. Amariglio Ana Baena Edmarie Guzmán-Vélez Yamile Bocanegra Justin S. Sanchez Eric M. Reiman Keith A. Johnson Reisa A. Sperling Francisco Lopera Dorene M. Rentz Yakeel T. Quiroz |
spellingShingle |
Clara Vila-Castelar Nathalia Muñoz Kathryn V. Papp Rebecca E. Amariglio Ana Baena Edmarie Guzmán-Vélez Yamile Bocanegra Justin S. Sanchez Eric M. Reiman Keith A. Johnson Reisa A. Sperling Francisco Lopera Dorene M. Rentz Yakeel T. Quiroz The Latin American Spanish version of the Face-Name Associative Memory Exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer’s disease Alzheimer’s Research & Therapy Alzheimer’s disease Autosomal dominant Alzheimer’s disease Neuropsychology Associative memory Imaging PET |
author_facet |
Clara Vila-Castelar Nathalia Muñoz Kathryn V. Papp Rebecca E. Amariglio Ana Baena Edmarie Guzmán-Vélez Yamile Bocanegra Justin S. Sanchez Eric M. Reiman Keith A. Johnson Reisa A. Sperling Francisco Lopera Dorene M. Rentz Yakeel T. Quiroz |
author_sort |
Clara Vila-Castelar |
title |
The Latin American Spanish version of the Face-Name Associative Memory Exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer’s disease |
title_short |
The Latin American Spanish version of the Face-Name Associative Memory Exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer’s disease |
title_full |
The Latin American Spanish version of the Face-Name Associative Memory Exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer’s disease |
title_fullStr |
The Latin American Spanish version of the Face-Name Associative Memory Exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer’s disease |
title_full_unstemmed |
The Latin American Spanish version of the Face-Name Associative Memory Exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer’s disease |
title_sort |
latin american spanish version of the face-name associative memory exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant alzheimer’s disease |
publisher |
BMC |
series |
Alzheimer’s Research & Therapy |
issn |
1758-9193 |
publishDate |
2020-09-01 |
description |
Abstract Background To determine whether performance on the Latin American Spanish version of the Face-Name Associative Memory Exam (LAS-FNAME) can differentiate between cognitively intact carriers of an autosomal dominant Alzheimer’s disease mutation (E280A) in Presenilin-1, who are genetically determined to develop early-onset dementia, from matched non-carriers. We also sought to examine whether LAS-FNAME performance is associated with amyloid-β and regional tau burden in mutation carriers. Methods A total of 35 cognitively intact mutation carriers (age range 26–41), 19 symptomatic carriers, and 48 matched non-carriers (age range 27–44) completed a neuropsychological assessment including the LAS-FNAME. A subset of participants (31 carriers [12 symptomatic] and 35 non-carriers) traveled from Colombia to Boston to undergo positron emission tomography (PET) using Pittsburgh compound B to measure mean cortical amyloid-β and flortaucipir for regional tau. ANOVA analyses and Spearman correlations were used to examine group differences and relationships among LAS-FNAME performance and amyloid-β and tau accumulation. Results Compared to non-carriers, cognitively intact mutation carriers had lower scores on the LAS-FNAME Total Scores (p = .040). Across all carriers (including symptomatic carriers), higher levels of amyloid-β (r = − .436, p = .018) and regional tau in the entorhinal (r = − .394, p = .031) and inferior temporal cortex (r = − .563, p = .001) were associated with lower LAS-FNAME Total Scores. Conclusions Performance on the LAS-FNAME differentiated between cognitively intact mutation carriers from non-carriers and was associated with greater amyloid and tau burden when examining all carriers. Findings suggest that the LAS-FNAME is sensitive to early clinical and pathological changes and can potentially help track disease progression in Spanish-speaking individuals. |
topic |
Alzheimer’s disease Autosomal dominant Alzheimer’s disease Neuropsychology Associative memory Imaging PET |
url |
http://link.springer.com/article/10.1186/s13195-020-00671-w |
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